机构：[1]Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.[2]Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.[3]Centers for Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.[4]Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.[5]Department of Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.[6]Department of Cardiovascular Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.昆明医科大学附属第一医院[7]Department of Ultrasound, Xijing Hospital and Fourth Military Medical University, Xi’an, Shaanxi 710032, China.[8]Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University,Guangzhou, Guangdong 510080, China.[9]Institute of Metabolic Disease, Baylor Research Institute, 3500 Gaston Avenue, Dallas, TX 75246, USA.
Background: Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) the expression profile of NRs in human tissues, (2) how the NR expression is modulated during atherosclerosis and metabolic diseases, and (3) the overview of the role of NRs in inflammatory conditions are not fully understood. Methods: To determine whether and how the expression of NRs are regulated in physiological/pathological conditions, we took an experimental database analysis to determine expression of all 48 known NRs in 21 human and 17 murine tissues as well as in pathological conditions. Results: We made the following significant findings: (1) NRs are differentially expressed in tissues, which may be under regulation by oxygen sensors, angiogenesis pathway, stem cell master regulators, inflammasomes, and tissue hypo-/hypermethylation indexes; (2) NR sequence mutations are associated with increased risks for development of cancers and metabolic, cardiovascular, and autoimmune diseases; (3) NRs have less tendency to be upregulated than downregulated in cancers, and autoimmune and metabolic diseases, which may be regulated by inflammation pathways and mitochondrial energy enzymes; and (4) the innate immune sensor inflammasome/caspase-1 pathway regulates the expression of most NRs. Conclusions: Based on our findings, we propose a new paradigm that most nuclear receptors are anti-inflammatory homeostasis-associated molecular pattern receptors (HAMPRs). Our results have provided a novel insight on NRs as therapeutic targets in metabolic diseases, inflammations, and malignancies.
基金：
NIH grant to Drs. XF Yang, H. Wang, and ET
Choi (Grant No. HL131460-01); National Natural Science Foundation of China
(Grant No. 81560051) and the National Key R&D Program in the Twelfth Fiveyear
Plan (Grant No. 2014ZX09303305) to XS Cheng; and Natural Science
Foundation of China (Grant Nos. 81370371, 81570394) and Ministry of Education
of the People’s Republic of China (Grant No. B13037) to HM Tan.
第一作者机构：[1]Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.[2]Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.[6]Department of Cardiovascular Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
通讯作者：
通讯机构：[2]Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.[3]Centers for Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.[4]Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
推荐引用方式(GB/T 7714)：
Luqiao Wang,Gayani Nanayakkara,Qian Yang,et al.A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors[J].JOURNAL OF HEMATOLOGY & ONCOLOGY.2017,10:doi:10.1186/s13045-017-0526-8.
APA：
Luqiao Wang,Gayani Nanayakkara,Qian Yang,Hongmei Tan,Charles Drummer...&Xiaofeng Yang.(2017).A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors.JOURNAL OF HEMATOLOGY & ONCOLOGY,10,
MLA：
Luqiao Wang,et al."A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors".JOURNAL OF HEMATOLOGY & ONCOLOGY 10.(2017)
医学