机构：[1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming,Yunnan 650032, China昆明医科大学附属第一医院[2]Department of Internal Medicine, Yunnan Red Cross Gaoxin Hospital, Kunming, Yunnan 650032, China[3]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China昆明医科大学附属第一医院
Serotonin transporter linked polymorphic region (5-HTTLPR) was reported to associate with depression in systemic lupus erythematosus (SLE) patients by our team. To explore whether 5-HTTLPR plays a role in the pathogenesis of SLE, we tested 138 SLE patients and 138 age and sex matched health controls (HCs) for 5-HTTLPR by polymerase chain reaction (PCR) and agarose gel electrophoresis. Interestingly, the results suggest that the frequencies of SS genotype and S allele in SLE patients with positive anti-Sm antibody and anti-U1RNP antibody were both significantly higher than the other genotypes and alleles. However, the frequencies of 5-HTTLPR genotypes and alleles were of no significant difference between SLE patients and HCs. This suggested that 5-HTTLPR was not a high-risk susceptible gene in SLE but might relate to SLE by affecting production of some autoantibodies, especially anti-Sm and anti-U1RNP antibody.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81160379, 81460256, 81560233, 81501406]; Ministry of Science and Technology of Yunnan Province [2012FB158]; Yunnan Provincial Health Science and Technology Plan [2014NS171, 2014NS172]; Yunnan Provincial Public Health for Academic Leader [D-201218, D-201239]; Yunnan Provincial Fund for Preparatory Young Leaders in Academia and Technology [2015HB071]
第一作者机构：[1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming,Yunnan 650032, China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Shu,Liu Shuang,Chen Fan,et al.Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus[J].JOURNAL OF IMMUNOLOGY RESEARCH.2016,2016:doi:10.1155/2016/3042726.
APA：
Li, Shu,Liu, Shuang,Chen, Fan,Cheng, Yuqi,Bai, Ru...&Xu, Jian.(2016).Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus.JOURNAL OF IMMUNOLOGY RESEARCH,2016,
MLA：
Li, Shu,et al."Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus".JOURNAL OF IMMUNOLOGY RESEARCH 2016.(2016)
