详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese

49| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Yunnan, China [2]Kunming College of Life Sciences, University of Chinese Academy of Sciences, Yunnan, China and [3]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Yunnan, China.

出处：

DOI：

ISSN：

摘要：

Complement factor H (CFH) is an essential regulator in the homeostasis of the complement system that plays multiple roles in leprosy. We previously reported a preliminary association of CFH with leprosy, but potentially causal variants remain to be identified. In this study, we performed a fine-mapping association analysis in 1110 individuals (527 leprosy patients and 583 controls) followed by bioinformatic analyses. We identified no association of typical missense CFH variants with leprosy and factor H-binding protein was not detected in Mycobacterium leprae. However, robust associations (P-Bonferroni < 0.003) of several CFH intronic tag single-nucleotide polymorphisms with leprosy were observed. Expression quantitative trait locus analysis showed that these leprosy-protective alleles were associated with higher CFH level and lower CFHR3 (complement factor H-related 3) level. Our results indicated that CFH variants may contribute to leprosy pathogenesis through altering CFH expression, leading to regulation of complement activity rather than mediating immune evasion by bacteria binding.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2014]版：

大类 | 2 区医学

小类 | 3 区遗传学 3 区免疫学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区遗传学 4 区免疫学

JCR分区：

出版当年[2013]版：

Q2 GENETICS & HEREDITY Q2 IMMUNOLOGY

最新[2023]版：

Q1 GENETICS & HEREDITY Q2 IMMUNOLOGY

影响因子： 5 最新[2023版] 3.8 最新五年平均 3.789 出版当年[2013版] 3.37 出版当年五年平均 3.675 出版前一年[2012版] 2.913 出版后一年[2014版]

第一作者：

第一作者机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Yunnan, China [2]Kunming College of Life Sciences, University of Chinese Academy of Sciences, Yunnan, China and

通讯作者：

通讯机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Yunnan, China [2]Kunming College of Life Sciences, University of Chinese Academy of Sciences, Yunnan, China and [3]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Yunnan, China. [*1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China [*2]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Yunnan 650032, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：