机构：[1]Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China,[2]Reproductive Medicine Center, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, People’s Republic of China,[3]Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People’s Republic of China,[4]Chongqing Reproductive and Genetics Institute, Chongqing Obstetrics and Gynecology Hospital, Chongqing, People’s Republic of China,[5]Reproductive Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, People’s Republic of China,华中科技大学同济医学院附属同济医院[6]Reproductive Medicine Centre, Women and Children Hospital of Jiangxi Province, Nanchang, People’s Republic of China,[7]Reproductive Medicine Center, First People’s Hospital of Yunnan Province, Kunming, People’s Republic of China,门急诊片生殖医学科云南省第一人民医院[8]Reproductive Medicine Center, Maternal and Child Health Care Hospital of Shaanxi Province, Xi’an, People’s Republic of China,[9]Reproductive Medicine Center, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, People’s Republic of China,中山大学附属第一医院[10]Reproductive Medicine Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China,[11]Reproductive Medicine Center, Henan Provincial People’s Hospital, Zhengzhou, People’s Republic of China,[12]Reproductive Medicine Center, Renji Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China,[13]Reproductive Medicine Center, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China,[14]Reproductive Medicine Center, Affiliated Hospital of Hainan Medical College, Haikou, People’s Republic of China,[15]Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academic of Medical Sciences, Beijing, People’s Republic of China,[16]Reproductive Medicine Center, Maternal and Children’s Health Hospital of Fujian Province, Fuzhou, People’s Republic of China,[17]Reproductive Medicine Center, Boai Hospital of Zhongshan, Zhongshan, People’s Public of China,[18]Reproductive Medicine Center, Women and Children’s Hospital of Shanxi Province, Taiyuan, People’s Republic of China
In order to study the impact of procedures of IVF/ICSI technology on sex ratio in China, we conducted this multi-center retrospective study including 121,247 babies born to 93,895 women in China. There were 62,700 male babies and 58,477 female babies, making the sex ratio being 51.8% (Male: Female = 107: 100). In univariate logistic regression analysis, sex ratio was imbalance toward females of 50.3% when ICSI was preformed compared to 47.7% when IVF was used (P < 0.01). The sex ratio in IVF/ICSI babies was significantly higher toward males in transfers of blastocyst (54.9%) and thawed embryo (52.4%) when compared with transfers of cleavage stage embryo (51.4%) and fresh embryo (51.5%), respectively. Multiple delivery was not associated with sex ratio. However, in multivariable logistic regression analysis after controlling for related factors, only ICSI (adjusted OR = 0.90, 95%CI: 0.88-0.93; P < 0.01) and blastocyst transfer (adjusted OR = 1.14, 95% CI: 1.09-1.20; P < 0.01) were associated with sex ratio in IVF/ICSI babies. In conclusion, the live birth sex ratio in IVF/ICSI babies was influenced by the use of ICSI, which may decrease the percentage of male offspring, or the use of blastocyst transfer, which may increase the percentage of male offspring.
第一作者机构：[1]Reproductive Medicine Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China,
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通讯作者：
推荐引用方式(GB/T 7714)：
Zhiqin Bu,Zi-Jiang Chen,Guoning Huang,et al.Live Birth Sex Ratio after In Vitro Fertilization and Embryo Transfer in China - An Analysis of 121,247 Babies from 18 Centers[J].PLOS ONE.2014,9(11):doi:10.1371/journal.pone.0113522.
APA：
Zhiqin Bu,Zi-Jiang Chen,Guoning Huang,Hanwang Zhang,Qiongfang Wu...&Yingpu Sun.(2014).Live Birth Sex Ratio after In Vitro Fertilization and Embryo Transfer in China - An Analysis of 121,247 Babies from 18 Centers.PLOS ONE,9,(11)
MLA：
Zhiqin Bu,et al."Live Birth Sex Ratio after In Vitro Fertilization and Embryo Transfer in China - An Analysis of 121,247 Babies from 18 Centers".PLOS ONE 9..11(2014)
