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TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway(Open Access)

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收录情况： ◇ SCIE

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机构： [a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China [b]University of the Chinese Academy of Sciences, Beijing, 101407, China [c]Medical Faculty of Kunming University of Science and Technology, Kunming, Yunnan [d]Department of breast surgery, The second hospital of Shanxi medical University, Taiyuan, 030071, China [e]Department of Urology of the First People’s Hospital of Yunnan Province, Kunming, 650032, China [f]Breast surgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China [g]KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China

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Breast cancer patients often suffer from disease relapse and metastasis due to the presence of breast cancer stem-like cells (BCSCs). Numerous studies have reported that high levels of inflammatory factors, including tumor necrosis factor alpha (TNF-α), promote BCSCs. However, the mechanism by which TNF-α promotes BCSCs is unclear. In this study, we demonstrate that TNF-α up-regulates TAZ, a transcriptional co-activator promoting BCSC self-renewal capacity in human breast cancer cell lines. Depletion of TAZ abrogated the increase in BCSCs mediated by TNF-α. TAZ is induced by TNF-α through the non-canonical NF-κB pathway, and our findings suggest that TAZ plays a crucial role in inflammatory factor–promoted breast cancer stemness and could serve as a promising therapeutic target. © 2020, The Author(s).

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出版当年[2020]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

最新[2023]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

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出版当年[2019]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.8 最新[2023版] 4.3 最新五年平均 3.998 出版当年[2019版] 4.576 出版当年五年平均 4.011 出版前一年[2018版] 4.38 出版后一年[2020版]

第一作者：

第一作者机构： [a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China [b]University of the Chinese Academy of Sciences, Beijing, 101407, China [c]Medical Faculty of Kunming University of Science and Technology, Kunming, Yunnan

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通讯作者：

通讯机构： [a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China [g]KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China

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