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Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation

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机构： [1]The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Normal University, Shanghai 200234, China. [2]1st hospital affiliated to Kunming medical university, Kunming 650032, Yunnan, China

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关键词： nanozyme reactive oxygen species self-supply tumor therapy β-lapachone

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Nanozyme with the "dual identity" of enzymes and nanomaterials is an emerging strategy to mimic natural enzymes in bio-nanotechnology. However, how to improve the nanozyme-based therapeutic efficiency in vivo still remains a challenge. Herein, we fabricated a nanozyme platform ([email protected]3O4@Cu2-xS, named as MNPs) possessing peroxidase enzyme-like activity and then introduced β-lapachone (La) to assemble an effective nanozyme (LaMNPs) to boost the production of reactive oxygen species and upregulate the level of H2O2 by the released La in an acidic tumor microenvironment. As a proof of concept, LaMNPs were injected intravenously into mice model, resulting in a significant and efficient inhibition of the tumor growth. © 2020 American Chemical Society.

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最新[2023]版：

Q2 NANOSCIENCE & NANOTECHNOLOGY Q2 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 4.7 最新[2023版] 4.5 最新五年平均 0 出版当年[2019版] 0 出版当年五年平均 0 出版前一年[2018版]

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第一作者机构： [1]The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Normal University, Shanghai 200234, China.

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