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Mn12Ac inhibits the migration, invasion and epithelial mesenchymal transition of lung cancer cells by downregulating the Wnt/β catenin and PI3K/AKT signaling pathways(Open Access)

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机构： [1]Gruaduate School of Hebei Medical University, Shijiazhuang, Hebei 050017 [2]The Third Department of Surgery,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011 [3]School of Medicine, Kunming University,Kunming, Yunnan 650214 [4]First Department of Respiratory Medicine, Yan'an Hospital Affiliated to Kunming Medical University,Kunming, Yunnan 650051 [5]Department of Medicine, The People's Hospital of Economic and Technological Development Zone,Kunming, Yunnan 650000 [6]Department of Chemical Science and Technology, Kunming University, Kunming, Yunnan 650214 [7]Respiratory System Disease Prevention and Control of Public Service Platform of Science and Technology in Yunnan Province, Kunming, Yunnan 650000, P.R. China

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关键词： Epithelial-mesenchymal transition Manganese-12 acetate Migration Phosphoinositide 3-kinase Wnt

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Lung cancer is the leading cause of global cancer-associated mortality, therefore it is important to reveal the molecular mechanisms of lung cancer progression and to develop novel therapeutic targets. The results of the present study identified that manganese-12 acetate (Mn12Ac) was able to significantly inhibit the migration and invasion of A549 cells. Western blotting demonstrated that treatment with Mn12Ac was able to upregulate E-cadherin, and downregulate N cadherin and vimentin. It was also identified by a quantitative polymerase chain reaction analysis that Mn12Ac was able to reduce the mRNA expression levels of EMT-associated transcription factors Snail, Slug, Twist-related protein 1 and zinc finger E-box-binding homeobox 1. It was also demonstrated that Mn12Ac was able to reduce the expression levels of Wnt and β-catenin proteins, and suppress the phosphorylation of phosphoinositide 3-kinase (PI3K) and AKT in A549 cells. Notably, it was revealed that Mn12Ac was able to decrease the mRNA and protein expression levels of programmed death ligand-1. Taken together, the results suggested that Mn12Ac is able to inhibit cell migration, invasion and EMT in lung cancer cells by regulating the Wnt/β-catenin and PI3K/AKT signaling pathways. © 2018, Spandidos Publications. All rights reserved.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2017]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 2.5 最新[2023版] 2.4 最新五年平均 1.664 出版当年[2017版] 1.654 出版当年五年平均 1.39 出版前一年[2016版] 1.871 出版后一年[2018版]

第一作者：

第一作者机构： [1]Gruaduate School of Hebei Medical University, Shijiazhuang, Hebei 050017 [2]The Third Department of Surgery,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011

通讯作者：

通讯机构： [3]School of Medicine, Kunming University,Kunming, Yunnan 650214 [6]Department of Chemical Science and Technology, Kunming University, Kunming, Yunnan 650214 [7]Respiratory System Disease Prevention and Control of Public Service Platform of Science and Technology in Yunnan Province, Kunming, Yunnan 650000, P.R. China [*1]School of Medicine, Kunming University, 2 Puxin Road, Kunming, Yunnan 650214, P.R. China [*2]School of Medicine, Kunming University, 2 Puxin Road, Kunming, Yunnan 650214, P.R. ChinaDepartment of Chemical Science and Technology, Kunming University, 2 Puxin Road, Kunming, Yunnan 650214, P.R. China

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Mn12Ac inhibits the migration, invasion and epithelial mesenchymal transition of lung cancer cells by downregulating the Wnt/β catenin and PI3K/AKT signaling pathways(Open Access)

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