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Involvement of MicroRNAs in Diabetes and Its Complications

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机构： [a]Department of Endocrinology, First Affiliated Hospital, Kunming Medical University, 295 Xichang Rd., Wuhua Qu, Kunming, Yunnan [b]School of Computing, University of South Alabama, Mobile, AL

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关键词： Diabetes Diabetic complications Glucose homeostasis Insulin Insulin resistance MicroRNA

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Diabetes is a severe condition worldwide. It is characterized by chronic hyperglycemia and is caused by defects in insulin production, secretion, and action. Both genetic and environmental factors contribute to the development of type 1 and type 2 diabetes. The pathogenesis of diabetes is complex and the underlying molecular mechanisms are only partially understood. MicroRNAs (miRNAs) play a fundamental role in diabetes and its complications. This chapter focuses on the dysregulation of miRNAs involved in the regulation of pancreatic islet insulin production and secretion as well as action and signaling in peripheral tissues. The roles of miRNAs in the development of diabetic complications are also discussed. Modulating miRNA expression, by either upregulation or inhibition, holds a promise as a strategy for treating this metabolic disease. © Springer Science+Business Media LLC 2017.

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第一作者机构： [a]Department of Endocrinology, First Affiliated Hospital, Kunming Medical University, 295 Xichang Rd., Wuhua Qu, Kunming, Yunnan

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