机构：[1]Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041四川大学华西医院[2]Department of Gynecology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101[3]Institute of Molecular and Clinical Medicine, Kunming Medical University[4]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Kunming, Yunnan 650500, P.R. China
The identification of biomarkers and their interaction network involved in the processes of endometriosis is a critical step in understanding the underlying mechanisms of the disease. The aim of the present study was to construct biomarker networks of endometriosis that integrated human protein-protein interactions and known disease-causing genes. Endometriosis-associated genes were extracted from Genotator and DisGeNet and biomarker network and pathway analyses were constructed using atBioNet. Of 100 input genes, 96 were strongly mapped to six major modules. The majority of the pathways in the first module were associated with the proliferation of cancer cells, the enriched pathways in module B were associated with the immune system and infectious diseases, module C included pathways related to immune and metastasis, the enriched pathways in module D were associated with inflammatory processes, and the majority of the pathways in module E were related to replication and repair. The present approach identified known and potential biomarkers in endometriosis. The identified biomarker networks are highly enriched in biological pathways associated with endometriosis, which may provide further insight into the molecular mechanisms underlying endometriosis.
基金：
The present study was supported by grants from the National Natural Science Foundation of China (grant no. 81360336) and the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University (grant no. 2015FB017).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041
共同第一作者：
通讯作者：
通讯机构：[3]Institute of Molecular and Clinical Medicine, Kunming Medical University[4]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Kunming, Yunnan 650500, P.R. China[*1]Institute of Molecular and Clinical Medicine, Kunming Medical University, 1168 West Chunrong Road, Yuhua Street, Kunming, Yunnan 650500, P.R. China
推荐引用方式(GB/T 7714)：
HONG XIAO,LIHUA YANG,JIANJUN LIU,et al.Protein-protein interaction analysis to identify biomarker networks for endometriosis.[J].Experimental and therapeutic medicine.2017,14(5):4647-4654.doi:10.3892/etm.2017.5185.
APA：
HONG XIAO,LIHUA YANG,JIANJUN LIU,YANG JIAO,LIN LU&HONGBO ZHAO.(2017).Protein-protein interaction analysis to identify biomarker networks for endometriosis..Experimental and therapeutic medicine,14,(5)
MLA：
HONG XIAO,et al."Protein-protein interaction analysis to identify biomarker networks for endometriosis.".Experimental and therapeutic medicine 14..5(2017):4647-4654
