Reduction of unnecessary right ventricular pacing by managed ventricular pacing and search AV plus algorithms in pacemaker patients: 12-month follow-up results of a randomized study
机构:[1]Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangzhou, China广东省人民医院[2]Clinical EP Lab and Arrhythmic Center, Fuwai Hospital, Chinese Academy of MedicalSciences and Peking Union Medical College, 167 Beilishilu, Beijing 100037, China[3]Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine,Zhejiang, China浙江大学医学院附属第一医院[4]Department of Cardiology, Zhejiang Hospital, Zhejiang, China[5]Department of Cardiology, First Peoples’ Hospital of Yunnan Province, Yunnan, China云南省第一人民医院心血管内科内科片[6]Department ofCardiovascular, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China[7]Medtronic (Shanghai) Management Co., Ltd., Shanghai, China[8]Medtronic,Inc., MN, USA
Aims The present study was to assess the reduction of right ventricular pacing (RVP) by pacemaker algorithms of Managed Ventricular Pacing (MVP) and Search AV+ (SAV+) interval over a period of 12 months. Methods and results A total of 385 patients indicated for a dual-chamber pacemaker (DC-PM) were enrolled in the prospective, randomized COMPARE study at 29 centres in China between June 2009 and April 2011. Patients implanted with DC-PMs were randomized in a 1 : 1 ratio to the MVP group or the SAV+ group. The percentage of VP (% VP) was obtained from the device diagnostic data at 1-, 6-, and 12-month follow-ups and was expressed as the median % VP over all beats in patients with sinus node dysfunction (SND) and atrioventricular block (AVB) excluding persistent third-degree AVB. Of 385 enrolled patients, 253 had SND and 72 had AVB. The % VP in the MVP group was significantly lower than that in the SAV+ group at 1-, 6-, and 12-month follow-ups, respectively. At 12-month follow-up, the median % VP in SND patients was 0.20% in the MVP group and 1.4% in the SAV+ group (P < 0.0001) and the median % VP in AVB patients was 11.8% in the MVP group and 98.1% in the SAV+ group (P < 0.001). There was no statistical difference in % VP from 1-to 12-month follow-up. A trend in the correlation between % VP and AT/AF burden was observed. Conclusion Over 12-month follow-up, the % VP was lower for MVP than SAV+ in patients with either SND or AVB. The sustainable % VP reduction has potential implications in reducing the development of heart failure and/or atrial arrhythmia morbidity.
第一作者机构:[1]Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangzhou, China
通讯作者:
推荐引用方式(GB/T 7714):
SilinChen,KepingChen,QianminTao,et al.Reduction of unnecessary right ventricular pacing by managed ventricular pacing and search AV plus algorithms in pacemaker patients: 12-month follow-up results of a randomized study[J].EUROPACE.2014,16(11):1595-1602.doi:10.1093/europace/euu055.
APA:
SilinChen,KepingChen,QianminTao,LiangrongZheng,FarongShen...&for the COMPARE Study Investigators.(2014).Reduction of unnecessary right ventricular pacing by managed ventricular pacing and search AV plus algorithms in pacemaker patients: 12-month follow-up results of a randomized study.EUROPACE,16,(11)
MLA:
SilinChen,et al."Reduction of unnecessary right ventricular pacing by managed ventricular pacing and search AV plus algorithms in pacemaker patients: 12-month follow-up results of a randomized study".EUROPACE 16..11(2014):1595-1602