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Effect of body mass index on the outcomes of controlled ovarian hyperstimulation in Chinese women with polycystic ovary syndrome: a multicenter, prospective, observational study(Open Access)

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机构: [1]Center for Reproductive Medicine, Shandong University,Jinan, China [2]Reproductive & Genetic Hospital CITIC-Xiangya, Changsha, China [3]Jiangsu Province Hospital, Nanjing, China [4]The Sixth Affiliated Hospital of Sun Yat-Sen University,Guangzhou, China [5]The First People’s Hospital of Yunnan Province, Kunming, China [6]The First Hospital of Lanzhou University, Lanzhou, China [7]Sir Run Run Shaw Hospital, School of Medicine, ZhejiangUniversity, Hangzhou, China [8]The First Affiliated Hospital of Zhengzhou University,Zhengzhou, China [9]Renji Hospital, Shanghai Jiaotong University School of Medicine,Shanghai, China [10]Merck Serono Co., Ltd, Beijing, China
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关键词: Body mass index In vitro fertilization Intracytoplasmic sperm injections Polycystic ovary syndrome Pregnancy rate

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Purpose: The purpose of the present study is to explore the influence of body mass index (BMI) on outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) techniques in Chinese women with polycystic ovary syndrome (PCOS). Methods: This was a multicenter, prospective, observational study that enrolled 800 subjects with PCOS from nine hospitals in China. Patients were categorized according to BMI categories: underweight, <18.5 kg/m2; normal, 19–23.9 kg/m2; overweight, 24–27.9 kg/m2; and obese, ≥28 kg/m2. Total recombinant follicle-stimulating hormone (rFSH) dose used, estradiol, and progesterone levels on human chorionic gonadotropin (hCG) day; implantation rate; and biochemical, clinical, and ongoing pregnancy rates were compared among BMI categories. Hormone levels (estradiol, follicle-stimulating hormone (FSH), LH, testosterone, and progesterone) were measured using electrochemiluminescence assays. Results: Among the 774 subjects, 27.3 % were overweight and 8.1 % were obese. The rFSH dose used differed significantly among BMI categories (P < 0.001). The implantation rate was lower in obese subjects than that in normal-weight subjects (25.3 vs 45.7 %). Clinical pregnancy rate per transfer differed among BMI categories (P = 0.033), but there was no difference for biochemical (P = 0.327) and ongoing (P = 0.084) pregnancy rates. The miscarriage rate was similar among BMI categories. Conclusions: More than one third of Chinese women with PCOS undergoing IVF/ICSI are overweight or obese. Elevated BMI is associated with reduced clinical pregnancy rate but similar ongoing pregnancy rates, suggesting that BMI has little impact on IVF outcomes. © 2016, Springer Science+Business Media New York.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 3 区 妇产科学 4 区 遗传学 4 区 生殖生物学
最新[2025]版:
大类 | 3 区 医学
小类 | 2 区 生殖生物学 3 区 遗传学 3 区 妇产科学
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出版当年[2016]版:
Q2 OBSTETRICS & GYNECOLOGY Q3 GENETICS & HEREDITY Q3 REPRODUCTIVE BIOLOGY
最新[2023]版:
Q1 OBSTETRICS & GYNECOLOGY Q2 GENETICS & HEREDITY Q2 REPRODUCTIVE BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Center for Reproductive Medicine, Shandong University,Jinan, China
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