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Strategy of blood pressure intervention in the elderly hypertensive patients (STEP): Rational, design, and baseline characteristics for the main trial

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机构: [1]Peking Union Med Coll & Chinese Acad Med Sci, FuWai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis,Hypertens Ctr, Beijing 100037, Peoples R China [2]Kailuan Gen Hosp, Tangshan 063000, Hebei, Peoples R China [3]Shanxi Acad Med Sci, Shanxi Dayi Hosp, Taiyuan 030032, Shanxi, Peoples R China [4]Sichuan Univ, West China Hosp, Chengdu 610041, Sichuan, Peoples R China [5]Guangdong Cardiovasc Inst, Guangzhou 510080, Guangdong, Peoples R China [6]Wuhan Univ, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China [7]Kang Ya Hosp, Yiyang 413000, Hunan, Peoples R China [8]Peoples Hosp Ji Xian Dist, Tianjin 301900, Peoples R China [9]Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian 710061, Shanxi, Peoples R China [10]Dalian Med Univ, Affiliated Hosp 1, Dalian 116011, Liaoning, Peoples R China [11]Fuwai Yunnan Cardiovasc Hosp, Kunming 650106, Yunnan, Peoples R China [12]Logist Univ PAPF, Pingjin Hosp, Tianjin 300162, Peoples R China [13]Natl Taiwan Univ, Coll Med, Taipei 10051, Taiwan [14]Jichi Med Univ, Sch Med, Shimotsuke, Tochigi 3290498, Japan
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关键词: Randomized clinical trial Essential hypertension Systolic blood pressure Major adverse cardiovascular events Mobile applications

摘要:
The optimal systolic blood pressure (SBP) treatment target in elderly people is full of challenge, and non-adherence is one major cause of uncontrolled BP. The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial is a multi-center, randomized controlled trial that aims to examine whether an intensive treatment (110 <= SBP < 130 mmHg) will provide more benefits in lowering cardiovascular events than a mild treatment (130 <= SBP < 150 mmHg) among people aged 60-80 years. From January 10, 2017 to December 31, 2017, 8511 patients with primary hypertension were recruited at 42 clinical centers throughout China and randomly assigned to the intensive or standard treatment in 1:1 ratio, in which clinical sites are considered as a stratification factor in randomization. Participants will be followed for an average of four years. All participants used the same validated home BP device and all centers used the same validated office BP device which can automatically upload the readings to a data center. The hospitals were randomly classified as the smartphone-based App center or usual care center in 1:1 ratio for the secondary purpose to study the effect of App management on BP control. In this trial, mean age of participants was 66.2 +/- 4.8 years, 24.1% were in the range of 70-80 years, and 65% were at high-risk with the 10-year Framingham risk score >= 15%. In conclusion, STEP will provide evidence not only to address appropriate target of BP control among hypertensive patients aged 60-80 years, but also to assess an effective model of App management for hypertension.

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出版当年[2020]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验 4 区 药学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 医学:研究与实验 3 区 药学
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出版当年[2019]版:
Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 PHARMACOLOGY & PHARMACY
最新[2023]版:
Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q3 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [1]Peking Union Med Coll & Chinese Acad Med Sci, FuWai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis,Hypertens Ctr, Beijing 100037, Peoples R China
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