机构：[1]Center for Infectious Diseases, Beijing You’an Hospital, Capital Medical University, Beijing, 100069, China[2]Infectious Diseases Department, Yunnan AIDS Caring Center, Kunming, Yunnan, 650301, China[3]The AaronDiamond AIDS Research Center, New York, NY, 10016, United States[4]Infectious Diseases Department, LongtanHospital of Guangxi, Liuzhou, Guangxi, 545005, China[5]Infectious Diseases Department, the Third People’s Hospitalof Kunming, Kunming, Yunnan, 650041, China[6]Infectious Diseases Department, the Infectious Diseases Hospitalof Chengdu, Chengdu, Sichuan, 610061, China[7]Institute of Infectious Diseases, the Eighth People’s Hospitalof Guangzhou, Guangzhou, Guangdong, 510060, China[8]Department of AIDS, Chongqing Infectious DiseaseMedical Center, Chongqing, 400039, China[9]Department of Infectious Diseases, the Fifth People’s Hospital ofGuiyang, Guiyang, Guizhou, 550004, China[10]Department of Clinical AIDS Research, the Third People’s Hospitalof Shenzhen, Shenzhen, Guangdong, 518020, China深圳市康宁医院深圳医学信息中心[11]Department of Hematology, the Third People’s Hospital ofHengyang, Hengyang, Hunan, 421000, China[12]Department of Infectious Diseases, the Second People’s Hospitalof Tianjin, Tianjin, 300193, China[13]Department of Infectious Diseases, the People’s Hospital of Luzhai, Liuzhou,Guangxi, 545600, China[14]Department of Infectious Diseases, the First Affiliated Hospital of Harbin MedicalUniversity, Harbin, Heilongjiang, 150001, China[15]Department of Infectious Diseases, Wuhan Medical TreatmentCenter, Wuhan, Hubei, 430023, China[16]Department of Infectious Diseases, Beijing Ditan Hospital, Capital MedicalUniversity, Beijing, 100015, China[17]Department of Infectious Diseases, the Second Hospital of Nanjing Affiliatedto Southeast University Medical College, Nanjing, Jiangsu, 210003, China[18]Department of Infectious Diseases,the Fourth People’s Hospital of Nanning, Nanning, Guangxi, 530023, China[19]Department of Infectious Diseases,the Sixth People’s Hospital of Hangzhou, Hangzhou, Jiangsu, 310023, China[20]Department of Infectious Diseases,Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, 200083, China[21]Departmentof Infectious Diseases, the First People’s Hospital of Changsha, Changsha, Hunan, 410005, China[22]School ofBiomedical Engineering, Capital Medical University, Beijing, 100069, China
This study evaluated the prevalence and factors associated with sleep disturbance in a large cohort of HIV-infected patients across China. A cross-sectional study was conducted among HIV-infected patients on antiretroviral therapy at 20 AIDS clinics. The Pittsburgh Sleep Quality Index was self-administered by subjects. Socio-demographic characteristics, medical history and HIV-related clinical data were collected. 4103 patients had complete data for analysis. Sleep disturbances were observed in 43.1% of patients. Associated factors in multivariable analysis included psychological factors: anxiety (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.44-4.00; P < 0.001), depression (OR, 2.09; 95% CI, 1.70-2.57; P < 0.001), and both anxiety and depression (OR, 5.90; 95% CI, 4.86-7.16; P < 0.001); sociodemographic factors: MSM (OR, 1.26; 95% CI, 1.04-1.52; P = 0.018), being single (OR, 1.45; 95% CI 1.21-1.74; P < 0.001), higher education (OR, 1.25; 95% CI, 1.03-1.53; P = 0.025); and clinical factors: suboptimal adherence (OR, 1.51; 95% CI, 1.23-1.85; P < 0.001), regimen-switching (OR, 1.94; 95% CI, 1.12-3.35; P = 0.018), and antidepressant use (OR, 1.98; 95% CI, 1.47-2.67; P = 0.044). Prevalence of sleep disturbance is high in this large Chinese cohort. Associated factors appear related to psychological and social-demographic factors. Health workers may consider routinely assessing sleep disturbances among HIV-infected patients, especially in the first three months after HIV diagnosis, and referring for mental health services, which may positively impact adherence to treatment.
基金：
Major Project of Beijing Municipal Science and Technology Committee [D141100000314005, D141100000314002, D131100005313005]; Beijing Key Laboratory [BZ0089]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZY201401]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81501731]
第一作者机构：[1]Center for Infectious Diseases, Beijing You’an Hospital, Capital Medical University, Beijing, 100069, China
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推荐引用方式(GB/T 7714)：
Xiaojie Huang,Huiqin Li,Kathrine Meyers,et al.Burden of sleep disturbances and associated risk factors: A cross-sectional survey among HIV-infected persons on antiretroviral therapy across China[J].SCIENTIFIC REPORTS.2017,7:doi:10.1038/s41598-017-03968-3.
APA：
Xiaojie Huang,Huiqin Li,Kathrine Meyers,Wei Xia,Zhihao Meng...&Hao Wu.(2017).Burden of sleep disturbances and associated risk factors: A cross-sectional survey among HIV-infected persons on antiretroviral therapy across China.SCIENTIFIC REPORTS,7,
MLA：
Xiaojie Huang,et al."Burden of sleep disturbances and associated risk factors: A cross-sectional survey among HIV-infected persons on antiretroviral therapy across China".SCIENTIFIC REPORTS 7.(2017)
