Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry VI: Effect of Cigarette Smoking on the Clinical Phenotype of Chinese Patients with Systemic Lupus Erythematosus
机构：[1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College &Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministryof Education, No.1 Shuaifuyuan, Beijing, 100730, China[2]Department of Rheumatology, Beijing TongrenHospital Affiliated to Capital Medical University, NO 1, Dong Jiao Min Xiang, Eastern District, Beijing, 100730,China首都医科大学附属同仁医院[3]Department of Rheumatology, the First Affiliated Hospital of Shantou University Medical College,No.57 ChangPingLu, Shantou, 515041, China[4]Department of Rheumatology, the First Affiliated Hospital ofAnhui Medical University, No.218 JiXiLu, Hefei, 230022, China[5]Department of Rheumatology, ZhongshanHospital Affiliated to Fudan University, No.180 FengLinLu, Shanghai, 200032, China[6]Department ofRheumatology, the General Hospital of Tianjing Medical University, No.154 AnShanDao, Tianjing, 300052,China[7]Department of Rheumatology, Capital Institute of Pediatrics, No.2 YaBaoLu, Beijing, 100020,China首都儿科研究所[8]Department of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University, No.600TianHeLu, Guangzhou, 510630, China中山大学附属第三医院[9]Department of Rheumatology, the Second Affiliated Hospital ofGuangzhou Medical College, No.107 YanJiangXiLu, Guangzhou, 510120, China[10]Department ofRheumatology, the Second Xiangya Hospital of Central South University, No.139 RenMinZhongLu,Changsha, 410011, China
Objectives Our study aimed to investigate the effect of cigarette smoking on the clinical phenotype of patients registered in the Chinese Systemic Lupus Erythematosus (SLE) Treatment and Research (CSTAR) group registry database, the first online registry of Chinese patients with SLE. Methods A prospective cross-sectional study of Chinese SLE patients was conducted using the CSTAR. Our case-control analysis was performed on age-and gender-matched subjects to explore the potential effect of cigarette smoking on the clinical manifestation of SLE. Results Smokers comprised 8.9% (65/730) of patients, and the ratio of females/males was 19/46. Thirty-nine patients were current smokers, and 26 were ex-smokers. Data showed significant differences between smokers and nonsmokers in the following areas: nephropathy (58.5% vs. 39.2%; p = 0.003), microscopic hematuria (30.8% vs. 19.1%; p = 0.025), proteinuria (53.8% vs. 34.4%; p = 0.002), and SLE Disease Activity Index(DAI) scores (12.38 +/- 8.95 vs. 9.83 +/- 6.81; p = 0.028). After adjusting for age and gender, significant differences between smokers and nonsmokers were found with photosensitivity (35.9% vs. 18%; p = 0.006), nephropathy (59.4% vs. 39.8%; p = 0.011), and proteinuria (54.7% vs. 35.2%). Although smokers tended to have greater disease severity compared with nonsmokers (SLEDAI scores: 12.58 +/- 8.89 vs. 10.5 +/- 7.09), the difference was not significant (p = 0.081). Conclusions Cigarette smoking triggers the development and exacerbation of SLE, especially with respect to renal involvement. Chinese smokers with SLE should be advised to discontinue cigarette use.
基金：
Chinese National Key Technology R&D Program, Ministry of Science and Technology [2008BAI59B02]; Chinese National High Technology Research and Development Program, Ministry of Science and TechnologyNational High Technology Research and Development Program of China [2012AA02A513]
第一作者机构：[1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College &Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministryof Education, No.1 Shuaifuyuan, Beijing, 100730, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Dong Xu,Xin You,Zhengang Wang,et al.Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry VI: Effect of Cigarette Smoking on the Clinical Phenotype of Chinese Patients with Systemic Lupus Erythematosus[J].PLOS ONE.2015,10(8):doi:10.1371/journal.pone.0134451.
APA：
Dong Xu,Xin You,Zhengang Wang,Qingyu Zeng,Jianhua Xu...&Xiaofeng Zeng.(2015).Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry VI: Effect of Cigarette Smoking on the Clinical Phenotype of Chinese Patients with Systemic Lupus Erythematosus.PLOS ONE,10,(8)
MLA：
Dong Xu,et al."Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry VI: Effect of Cigarette Smoking on the Clinical Phenotype of Chinese Patients with Systemic Lupus Erythematosus".PLOS ONE 10..8(2015)
