High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program
机构：[1]The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China,[2]Quality control laboratory, China Bone Marrow Program, Beijing, China,[3]HLA Laboratory, Zhejiang Blood Center, Hangzhou, Zhejiang, China,[4]HLA Laboratory, Liaoning Blood Center, Shenyang, Liaoning, China,[5]HLA Laboratory, Chongqing Blood Center, Chongqing, China,[6]HLA Laboratory, Taiyuan Red Cross Blood Center, Taiyuan, Shanxi, China,[7]HLA Laboratory, Shaanxi Blood Center, Xi’an, Shaanxi, China,[8]HLA Laboratory, Beijing Red Cross Blood Center, Beijing, China,[9]HLA Laboratory, Henan Blood Center, Zhengzhou, Henan, China,[10]HLA Laboratory, Shandong Blood Center, Jinan, Shandong,[11]HLA Laboratory, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China,江苏省人民医院[12]The Key Laboratory of Histocompatibility and Immunogenetics, Shenzhen Blood Center, Shenzhen, Guangdong, China,[13]HLA Laboratory, Hebei Blood Center, Shijiazhuang, Hebei, China,[14]HLA Laboratory, Dalian Red Cross Blood Center, Dalian, Liaoning, China,[15]HLA Laboratory, Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu, Sichuan, China,[16]HLA Laboratory, Xinjiang Blood Center, Urumchi, Xinjiang, China,[17]HLA Laboratory, Kunming Blood Center, Kunming, Yunnan, China,[18]HLA Laboratory, Hefei Red Cross Blood Center, Hefei, Anhui, China,[19]HLA Laboratory, Gansu Red Cross Blood Center, Lanzhou, Gansu, China,[20]HLA Laboratory, Jiangxi Blood Center, Nanchang, Jiangxi, China,[21]HLA Laboratory, Nanning Blood Center, Nanning, Guangxi, China,[22]HLA Laboratory, Xiamen Blood Center, Xiamen, Fujian, China,[23]HLA Laboratory, Changchun Blood Center, Changchun, Jilin, China,[24]HLA Laboratory, Wuhan Blood Center, Wuhan, Hubei, China,[25]HLA Laboratory, Harbin Red Cross Blood Center, Harbin, Heilongjiang, China,[26]HLA Laboratory, Qingdao Blood Center, Qingdao, Shandong, China,[27]HLA Laboratory, Yueyang Red Cross Blood Center, Yueyang, Hunan, China,[28]HLA Laboratory, Changsha Blood Center, Changsha, Hunan, China,[29]HLA Laboratory, Soochow Red Cross Blood Center, Suzhou, Jiangsu, China,[30]HLA Laboratory, Shanghai Blood Center, Shanghai, China,[31]HLA Laboratory, BFR Transplant Diagnostic Service Center, Beijing China,[32]HLA Laboratory, CapitalBio Corporation, Beijing, China,[33]HLA Laboratory, Beijing Genomics Institute, Shenzhen, Guangdong, China,[34]Department of HLA Technology, China Bone Marrow Program, Beijing, China
Allogeneic hematopoietic stem cell transplantation is a widely used and effective therapy for hematopoietic malignant diseases and numerous other disorders. High-resolution human leukocyte antigen (HLA) haplotype frequency distributions not only facilitate individual donor searches but also determine the probability with which a particular patient can find HLA-matched donors in a registry. The frequencies of the HLA-A, -B, -C, -DRB1, and -DQB1 alleles and haplotypes were estimated among 169,995 Chinese volunteers using the sequencing-based typing (SBT) method. Totals of 191 HLA-A, 244 HLA-B, 146 HLA-C, 143 HLA-DRB1 and 47 HLA-DQB1 alleles were observed, which accounted for 6.98%, 7.06%, 6.46%, 9.11% and 7.91%, respectively, of the alleles in each locus in the world (IMGT 3.16 Release, Apr. 2014). Among the 100 most common haplotypes from the 169,995 individuals, nine distinct haplotypes displayed significant regionally specific distributions. Among these, three were predominant in the South China region (i.e., the 20th, 31st, and 81sthaplotypes), another three were predominant in the Southwest China region (i.e., the 68th, 79th, and 95th haplotypes), one was predominant in the South and Southwest China regions (the 18th haplotype), one was relatively common in the Northeast and North China regions (the 94th haplotype), and one was common in the Northeast, North and Northwest China (the 40th haplotype). In conclusion, this is the first to analyze high-resolution HLA diversities across the entire country of China, based on a detailed and complete data set that covered 31 provinces, autonomous regions, and municipalities. Specifically, we also evaluated the HLA matching probabilities within and between geographic regions and analyzed the regional differences in the HLA diversities in China. We believe that the data presented in this study might be useful for unrelated HLA-matched donor searches, donor registry planning, population genetic studies, and anthropogenesis studies.
第一作者机构：[1]The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China,[2]Quality control laboratory, China Bone Marrow Program, Beijing, China,
通讯作者：
通讯机构：[1]The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China,[2]Quality control laboratory, China Bone Marrow Program, Beijing, China,
推荐引用方式(GB/T 7714)：
Xiao-Yang Zhou,Fa-Ming Zhu,Jian-Ping Li,et al.High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program[J].PLOS ONE.2015,10(9):doi:10.1371/journal.pone.0139485.
APA：
Xiao-Yang Zhou,Fa-Ming Zhu,Jian-Ping Li,Wei Mao,De-Mei Zhang...&Jian-Ping Cai.(2015).High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program.PLOS ONE,10,(9)
MLA：
Xiao-Yang Zhou,et al."High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program".PLOS ONE 10..9(2015)
