机构：[1]Department of Neurology, The First Affiliated Hospital of ChongqingMedical University, Chongqing 400016, China[2]NHC Key Laboratory ofDiagnosis and Treatment on Brain Functional Diseases, The First AffiliatedHospital of Chongqing Medical University, Chongqing 400016, China[3]Division of Life Sciences and Medicine, Department of Neurology, The FirstAffiliated Hospital of USTC, University of Science and Technology of China,Hefei, Anhui 230001, P.R.China[4]Department of Psychiatry, The First People’sHospital of Yunnan Province, Kunming 650032, Yunnan, China[5]Departmentof Neurology, Yongchuan Hospital of Chongqing Medical University,Chongqing 402160, China[6]Department of Neurology, First AffiliatedHospital, PLA General Hospital, Beijing 100048, China
BACKGROUND: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. METHODS: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated. RESULTS: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P < 0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analysis revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS. CONCLUSION: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients.
基金：
The Special Project on Natural Chronic Non-infectious Diseases
(2016YFC1307200) and the National Key Research and Development Program
of China (2017YFA0505700).
第一作者机构：[1]Department of Neurology, The First Affiliated Hospital of ChongqingMedical University, Chongqing 400016, China[2]NHC Key Laboratory ofDiagnosis and Treatment on Brain Functional Diseases, The First AffiliatedHospital of Chongqing Medical University, Chongqing 400016, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, The First Affiliated Hospital of ChongqingMedical University, Chongqing 400016, China[2]NHC Key Laboratory ofDiagnosis and Treatment on Brain Functional Diseases, The First AffiliatedHospital of Chongqing Medical University, Chongqing 400016, China
推荐引用方式(GB/T 7714)：
Wen-Song Yang,Rui Li,Yi-Qing Shen,et al.Importance of lipid ratios for predicting intracranial atherosclerotic stenosis(Open Access)[J].LIPIDS IN HEALTH AND DISEASE.2020,19(1):doi:10.1186/s12944-020-01336-1.
APA：
Wen-Song Yang,Rui Li,Yi-Qing Shen,Xing-Chen Wang,Qing-Jun Liu...&Peng Xie.(2020).Importance of lipid ratios for predicting intracranial atherosclerotic stenosis(Open Access).LIPIDS IN HEALTH AND DISEASE,19,(1)
MLA：
Wen-Song Yang,et al."Importance of lipid ratios for predicting intracranial atherosclerotic stenosis(Open Access)".LIPIDS IN HEALTH AND DISEASE 19..1(2020)
