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High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)2D3 to increase NGF secretion in a rat Schwann cell line RSC96

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收录情况： ◇ SCIE

作者：
Zhou, Y.-K[a] * ; Liang, Z[b] ; Guo, Y[c] ; Zhang, H.-T[d,*1] ; Wang, K.-H[e,*2] ;
机构： [a]Department of Endocrinology and Metabolism, First People's Hospital of Yunnan Province, The Kunhua Affiliated Hospital of Kunming Univ. of Science and Technology, Kunming, Yunnan, China [b]Department of Information Center, First People's Hospital of Yunnan Province, The Kunhua Affiliated Hospital of Kunming Univ. of Science and Technology, Kunming, Yunnan, China [c]The State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China [d]Chongqing Center for Biomedical Research and Equipment Development, Chongqing Academy of Science and Technology, Chongqing, China [e]Department of General Surgery, First People's Hospital of Yunnan Province, The Kunhua Affiliated Hospital of Kunming Univ. of Science and Technology, Kunming, Yunnan, China
出处：
DOI： 10.1016/j.mce.2015.01.005
ISSN：

关键词： 1 25(OH)2D3 CYP24A1 High glucose

摘要：
Vitamin D deficiency or insufficiency is an independent risk factor for diabetic peripheral neuropathy (DPN), but the relationship between 1,25(OH)2D3 and DPN remains unknown. We found that 1,25(OH)2D3 stimulated the secretion of nerve growth factor (NGF) in rat Schwann cell line RSC96, but ability of 1,25(OH)2D3 to increase NGF protein was impaired under high glucose conditions. High glucose upregulated the expression of CYP24A1 protein, which catalyzes the conversion of 1,25(OH)2D3 into inactive products, further impairing the ability of 1,25(OH)2D3 to upregulate NGF secretion in Schwann cells. Inhibition of CYP24A1 protein expression ameliorated the secretion of NGF in response to 1,25(OH)2D3. The findings of this study suggest that CYP24A1 protein plays an important role in the relationship between DPN and 1,25(OH)2D3. © 2015.

基金：
This work was funded by the Applied Basic Research Plans Program of Yunnan Province ( 2013FB204 ) and Gastrointestinal Surgery Innovation Team Project of Yunnan province ( 2012HC013 ), Health System Leading Talent Project of Yunnan province ( L-201205 ).
语种：
外文
被引次数：
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中科院(CAS)分区：
出版当年[2015]版：
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 内分泌学与代谢
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 内分泌学与代谢 3 区 细胞生物学
JCR分区：
出版当年[2014]版：
Q1 ENDOCRINOLOGY & METABOLISM Q2 CELL BIOLOGY
最新[2023]版：
Q2 ENDOCRINOLOGY & METABOLISM Q2 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [a]Department of Endocrinology and Metabolism, First People's Hospital of Yunnan Province, The Kunhua Affiliated Hospital of Kunming Univ. of Science and Technology, Kunming, Yunnan, China
通讯作者：
通讯机构： [d]Chongqing Center for Biomedical Research and Equipment Development, Chongqing Academy of Science and Technology, Chongqing, China [e]Department of General Surgery, First People's Hospital of Yunnan Province, The Kunhua Affiliated Hospital of Kunming Univ. of Science and Technology, Kunming, Yunnan, China [*1]Chongqing Center for Biomedical Research and Equipment Development, Chongqing Academy of Science and Technology, Chongqing 401123, China. [*2]Department of General Surgery, First People’s Hospital of Yunnan Province (The Kunhua Affiliated Hospital of Kunming University of Science and Technology), Kunming, Yunnan 650032, China.
推荐引用方式(GB/T 7714)：
Zhou Y.-K,Liang Z,Guo Y,et al.High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)2D3 to increase NGF secretion in a rat Schwann cell line RSC96[J].MOLECULAR AND CELLULAR ENDOCRINOLOGY.2015,404(C):75-81.doi:10.1016/j.mce.2015.01.005.
APA：
Zhou, Y.-K,Liang, Z,Guo, Y,Zhang, H.-T&Wang, K.-H.(2015).High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)2D3 to increase NGF secretion in a rat Schwann cell line RSC96.MOLECULAR AND CELLULAR ENDOCRINOLOGY,404,(C)
MLA：
Zhou, Y.-K,et al."High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)2D3 to increase NGF secretion in a rat Schwann cell line RSC96".MOLECULAR AND CELLULAR ENDOCRINOLOGY 404..C(2015):75-81

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