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An inverse relationship between iodine intake and thyroid antibodies: a national cross-sectional survey in mainland China.

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收录情况： ◇ SCIE

作者：
Teng Di[1] * ; Yang Wenqing[2] ; Shi Xiaoguang[3] ; Li Yongze[4] ; Ba Jianming[5] ; Chen Bing[6] ; Du Jianling[7] ; He Lanjie[8] ; Lai Xiaoyang[9] ; Li Yanbo[10] ; Chi Haiyi[11] ; Liao Eryuan[12] ; Liu Chao[13] ; Liu Libin[14] ; Qin Guijun[15] ; Qin Yingfen[16] ; Quan Huibiao[17] ; Shi Bingyin[18] ; Sun Hui[19] ; Tang Xulei[20] ; Tong Nanwei[21] ; Wang Guixia[22] ; Zhang Jin-An[23] ; Wang Youmin[24] ; Xue Yuanming[25] ; Yan Li[26] ; Yang Jing[27] ; Yang Lihui[28] ; Yao Yongli[29] ; Ye Zhen[30] ; Zhang Qiao[31] ; Zhang Lihui[32] ; Zhu Jun[33] ; Zhu Mei[34] ; Shan Zhongyan[35] ; Teng Weiping[36,37] ;
机构： [1]Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases,, Endocrinology and Metabolism, Shenyang, Liaoning, China [2]China Medical University First Hospital, 159407, Shenyang, Liaoning, China [3]China Medical University, Endocrinololgy and Metabolism, Nanjing Bei street 155, Heping district, Shenyang, China, 110001 [4]The First Hospital of China Medical University, Department of Endocrinology and Metabolism, Shenyang, Liaoning, China [5]Chinese PLA General Hospital, 104607, Dept. of Endocrinology, 28 Fuxing Road, Beijing, China, 100853 [6]Third Military Medical University Southwest Hospital, 388288, Chongqing, Chongqing, China [7]The First Affiliated Hospital of Dalian Medical University, 1021401, , China, 116011 [8]Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China [9]Nanchang University Second Affiliated Hospital, 196534, Nanchang, Jiangxi, China [10]First Affiliated Hospital of Harbin Medical University, 74559, Harbin, Heilongjiang, China [11]Hohhot First Hospital, Huhhot, China [12]Central South University, 12570, Changsha, Hunan, China [13]The First affiliated Hospital with Nanjing Medical University, Department of Endocrine and Metabolism, No.1, Huadian Road, Nanjing, Nanjing, Jiangsu, China, 210028 [14]Fujian Medical University Union Hospital, 117890, Xiamen, Fujian, China [15]Zhengzhou University First Affiliated Hospital, 191599, Zhengzhou, Henan, China [16]Guangxi Medical University First Affiliated Hospital, 117742, Nanning, Guangxi, China [17]Hainan General Hospital, 26496, Haikou, Hainan, China [18]Xi'an Jiaotong University, Dept. of Endocrinology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China, 710061 [19]Huazhong University of Science and Technology, 12443, Wuhan, Hubei , China [20]The First Hospital of Lanzhou University, Department of Endocrinology and Metabolism, Lanzhou, Gansu, China [21]Sichuan University, 12530, Chengdu, Sichuan, China [22]tongnw@scu.edu.cn. [22]Jilin University First Hospital, 117971,71 Xinmin st, Changchun, China, 130021 [23]Shanghai University of Medicine &amp [25]Health Sciences Affiliated Zhoupu Hospital, Department of Endocrinology, Shanghai, China [24]The First Hospital of An Hui Medical University, Hefei, China [25]The First People's Hospital of Yunnan Province, Kunming, China [26]The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, China [27]First Hospital of Shanxi Medical University, 105862, Taiyuan, Shanxi , China [28]People's Hospital of Tibet Autonomous Region, Lhasa, China [29]Qinghai Provincial People's Hospital, 159433, Xining, Qinghai, China [30]Zhejiang Provincial Center for Disease Control and Prevention, 117838, Hangzhou, Zhejiang, China [31]Affiliated Hospital of Guiyang Medical University, 74720, Guiyang, Guizhou, China [32]Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China [33]Xinjiang Medical University Affiliated First Hospital, 159427, Urumqi, Xinjiang, China [34]General Hospital, Tianjin Medical University, Endocrinology, No 154 Anshan Road, Tianjin, China, 300052 [35]the 1st hospital of China Medical University, Institute of Endocrinology, Department of Endocrinology and Metabolism, the 1st hospital of Chin, Shenyang, China, 100001 [36]the 1st hospital of China Medical University, Institute of Endocrinology, Department of Endocrinology and Metabolism, 155,Nanjing Bei Street, Heping District, Shenyang, Liaoning, China, 110001 [37]the first hospital of CMU, Department of endocrinology, 155,Nanjing Bei street, shenyang, Liaoning, China, 110001
出处：
DOI： 10.1089/thy.2020.0037
ISSN：

摘要：
Iodine intake is associated with thyroid autoimmunity. In this study, we evaluated the changes in thyroid autoimmunity after 20 years of universal salt iodization (USI) in China. A total of 78,470 subjects (18 y or older) from 31 provincial regions of mainland China participated in the study. Serum thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), TSH receptor antibody (TRAb), thyroid stimulating hormone (TSH), and urinary iodine concentration (UIC) were measured. Positive TPOAb and TgAb were detected in 10.19% (95% CI, 9.80% to 10.59%) and 9.70% (95% CI, 9.28% to 10.13%) of the subjects, respectively. The prevalence of positive isolated TPOAb (i-TPOAb), positive isolated TgAb (i-TgAb), and double positive TPOAb and TgAb (d-Ab) were 4.52%, 4.16%, and 5.94%, respectively. The prevalences of thyroid antibody positivity were the highest in the iodine deficient (UIC < 100 µg/L) groups. The prevalence of i-TPOAb was inversely associated with more than adequate iodine intake (MAI) and excessive iodine intake (EI); odds ratio (OR) was 0.89 (95% CI: 0.81-0.98) for MAI and 0.90 (95% CI: 0.81-0.99) for EI. We observed that i-TgAb, like i-TPOAb, was a high-risk factor for subnormal TSH levels (OR = 3.64, 95% CI: 2.62-5.05) and elevated TSH levels (OR = 1.62, 95% CI: 1.49-1.77). The prevalence of thyroid antibody positivity varied among five ethnic groups. After two decades of USI, the prevalence of thyroid antibody positivity has remained low. MAI and EI had an inverse relationship with TPOAb positivity, which reveals that UIC between 100 μg/L and 299 μg/L is optimal and safe for thyroid autoimmunity. These conclusions need to be confirmed in a follow-up study because this study was a cross-sectional study.

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中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 医学
小类 | 1 区 内分泌学与代谢
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 内分泌学与代谢
JCR分区：
出版当年[2019]版：
Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases,, Endocrinology and Metabolism, Shenyang, Liaoning, China
通讯作者：
通讯机构： [36]the 1st hospital of China Medical University, Institute of Endocrinology, Department of Endocrinology and Metabolism, 155,Nanjing Bei Street, Heping District, Shenyang, Liaoning, China, 110001 [37]the first hospital of CMU, Department of endocrinology, 155,Nanjing Bei street, shenyang, Liaoning, China, 110001
推荐引用方式(GB/T 7714)：
Teng Di,Yang Wenqing,Shi Xiaoguang,et al.An inverse relationship between iodine intake and thyroid antibodies: a national cross-sectional survey in mainland China.[J].THYROID.2020,30(11):1656-1665.doi:10.1089/thy.2020.0037.
APA：
Teng Di,Yang Wenqing,Shi Xiaoguang,Li Yongze,Ba Jianming...&Teng Weiping.(2020).An inverse relationship between iodine intake and thyroid antibodies: a national cross-sectional survey in mainland China..THYROID,30,(11)
MLA：
Teng Di,et al."An inverse relationship between iodine intake and thyroid antibodies: a national cross-sectional survey in mainland China.".THYROID 30..11(2020):1656-1665

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