Objective To analyse the characteristic finding of demyelinating disease on MR im-ages.Methods Look back on the 500 cases of demyelinating disease after make a diagnosis and givetreatment. Result According to experience we classify 500 cases into five clinical types, in which thereare chronic demyelinating cerebropathy of 420 cases (84.0%) ;acute demyelinating cerebritis of 51 cases( 10.2 % ); multiple sclerosis of 22 cases (4.4 % ); leukodystrophy of 6 cases ( 1.2 % ); leukemic infiltrat-ing brain is one (0.2%) rare case seen for the feature of MRI accord with the standard of demyelinatingdisease, thus we call special type. Conclusion We advance a new point of reversing and unable reerseddemyelination to carry out the prevention and treatment in early stage, so that come true effectiv in clinicalpractice.