机构：[1]Department of Clinical Laboratory, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, China医技片检验科云南省第一人民医院[2]Institute of Clinical and Basic Medical Sciences (Yunnan Provincial Key Laboratory of Clinical Virology,Key Laboratory for Birth Defects and Genetic Diseases), The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, China云南省第一人民医院[3]Department of Hematology, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, China内科片血液内科云南省第一人民医院
Macrophages within tissues display a strong plastic ability in respond to environmental cues in both physiologic influences and disease. However, the macrophage phenotype and its distribution in the bone marrow biopsies (BMB) samples of human acute leukemia (AL) remain poorly understood. In this study, 97 BMB samples of patients with acute leukemia and 30 iron-deficiency anemias (IDA) as control group were evaluated with immunohistochemistry. In comparison with controls, the counts of CD68(+), CD163(+), and CD206(+)macrophages were remarkably increased in BMB samples of acute leukemia (P < 0.01), as well as their infiltration density was roaring up-regulation (P < 0.01). The expression levels of CD68(+), CD163(+), and CD206(+)macrophages were decreased in patients with complete remission, but there still existed statistically significant contrast to the control group (P < 0.01). The ratios of the CD163-positive cells or CD206-positive cells to CD68-positive cells were most prevalent in the BMB samples of human acute leukemia compared with the control group (P < 0.01), which support that macrophages were polarized to M2 macrophages.
基金：
This work was supported by grants from “the
National Science Funding of China,” Grants: No.31460298, the
Foundation Dr. Sa YL and “the Basic Research on Application of Joint
Special Funding of Science and Technology Department of Yunnan
Province-Kunming Medical University,” Grants: No.2014FZ070, the
Foundation Mr. Song JX.
第一作者机构：[1]Department of Clinical Laboratory, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, China[2]Institute of Clinical and Basic Medical Sciences (Yunnan Provincial Key Laboratory of Clinical Virology,Key Laboratory for Birth Defects and Genetic Diseases), The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Song Jian-Xin,Wen Yan,Li Rui-Wei,et al.Phenotypic characterization of macrophages in the BMB sample of human acute leukemia[J].ANNALS OF HEMATOLOGY.2020,99(3):539-547.doi:10.1007/s00277-020-03912-y.
APA：
Song, Jian-Xin,Wen, Yan,Li, Rui-Wei,Dong, Ting,Tang, Yi-Fei...&Sa, Ya-Lian.(2020).Phenotypic characterization of macrophages in the BMB sample of human acute leukemia.ANNALS OF HEMATOLOGY,99,(3)
MLA：
Song, Jian-Xin,et al."Phenotypic characterization of macrophages in the BMB sample of human acute leukemia".ANNALS OF HEMATOLOGY 99..3(2020):539-547
