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Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy

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机构: [1]Medical School, Kunming University of Science and Technology, Kunming, People’s Republic of China [2]Department of Thoracic Surgery, The First People’s Hospital of Yunnan Province, Kunming, People’s Republic of China
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关键词: ferroptosis cancer iron autophagy p53

摘要:
Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 3 区 生物工程与应用微生物 4 区 肿瘤学
最新[2023]版:
大类 | 4 区 医学
小类 | 3 区 生物工程与应用微生物 4 区 肿瘤学
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出版当年[2018]版:
Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 ONCOLOGY
最新[2023]版:
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者机构: [1]Medical School, Kunming University of Science and Technology, Kunming, People’s Republic of China [*1]Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, People’s Republic of China
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通讯机构: [1]Medical School, Kunming University of Science and Technology, Kunming, People’s Republic of China [*1]Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, People’s Republic of China
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