机构:[1]Medical School, Kunming University of Science and Technology, Kunming, People’s Republic of China[2]Department of Thoracic Surgery, The First People’s Hospital of Yunnan Province, Kunming, People’s Republic of China外科片胸外科云南省第一人民医院
Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.
基金:
This study was funded by the National Natural Science
Foundation of China (No. 81760526 and No. 81802794)
and Yunnan Provincial Research Foundation for Basic
Research, China (No. 2018FB135).
第一作者机构:[1]Medical School, Kunming University of Science and Technology, Kunming, People’s Republic of China[*1]Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, People’s Republic of China
共同第一作者:
通讯作者:
通讯机构:[1]Medical School, Kunming University of Science and Technology, Kunming, People’s Republic of China[*1]Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, People’s Republic of China
推荐引用方式(GB/T 7714):
Shi Zhi-Zhou,Fan Ze-Wen,Chen Yun-Xia,et al.Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy[J].ONCOTARGETS AND THERAPY.2019,12:11291-11304.doi:10.2147/OTT.S232852.
APA:
Shi, Zhi-Zhou,Fan, Ze-Wen,Chen, Yun-Xia,Xie, Xiu-Feng,Jiang, Wen...&Bai, Jie.(2019).Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy.ONCOTARGETS AND THERAPY,12,
MLA:
Shi, Zhi-Zhou,et al."Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy".ONCOTARGETS AND THERAPY 12.(2019):11291-11304