机构：[1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China[2]Medical School, Kunming University of Science and Technology, Kunming, 650500, China[3]National Health Commission’s Key Laboratory for Healthy Births in Western China, Department of Obstetrics and Gynecology, First People’s Hospital of Yunnan Province, Kunming, 650032, China外科片产科妇科云南省第一人民医院
Recent in vitro and clinical studies have found that metformin (MET) may play a preventive or therapeutic role in preeclampsia (PE) and may be a candidate drug for the prevention and/or treatment of PE. In this study, we used lipopolysaccharide (LPS) to induce a PE-like rat model and investigated the intervention effect of MET from the perspectives of clinical manifestations, placental morphology, serum marker for placental injury, systemic inflammatory response and oxidative/nitrative stress, and placental nuclear factor-kappa B (NF-kappa B) signaling. The results showed that MET improved LPS-induced hypertension, proteinuria, fetal growth restriction (FGR) and stillbirth, alleviated placental injury and decreased maternal serum marker alpha-fetoprotein (MS-AFP) level; MET suppressed LPS-induced TNF-alpha and IL-6 productions, reduced oxidative/nitrative stress as evidenced by increased superoxide dismutase (SOD) activity, decreased inducible nitric oxide synthase (iNOS) activity, and decreased levels of malondialdehyde (MDA) and nitric oxide (NO); MET inhibited LPS-induced NF-kappa B activation in placentas. Based on these findings, it can be concluded that MET is beneficial to the PE-like rat model by protecting placentas from injury, suppressing systemic inflammatory response and oxidative/nitrative stress, and inhibiting placental NF-kappa B signaling pathway. MET is a promising drug for prevention and/or treatment of PE.
基金：
Grants of Fostering Leading Talents in Health System from the Health Department of Yunnan Province, China [201201]
第一作者机构：[1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China[2]Medical School, Kunming University of Science and Technology, Kunming, 650500, China
通讯作者：
通讯机构：[2]Medical School, Kunming University of Science and Technology, Kunming, 650500, China[3]National Health Commission’s Key Laboratory for Healthy Births in Western China, Department of Obstetrics and Gynecology, First People’s Hospital of Yunnan Province, Kunming, 650032, China
推荐引用方式(GB/T 7714)：
Hu Jilin,Zhang Jinman,Zhu Baosheng.Protective effect of metformin on a rat model of lipopolysaccharide-induced preeclampsia[J].FUNDAMENTAL & CLINICAL PHARMACOLOGY.2019,33(6):649-658.doi:10.1111/fcp.12501.
APA：
Hu, Jilin,Zhang, Jinman&Zhu, Baosheng.(2019).Protective effect of metformin on a rat model of lipopolysaccharide-induced preeclampsia.FUNDAMENTAL & CLINICAL PHARMACOLOGY,33,(6)
MLA：
Hu, Jilin,et al."Protective effect of metformin on a rat model of lipopolysaccharide-induced preeclampsia".FUNDAMENTAL & CLINICAL PHARMACOLOGY 33..6(2019):649-658
