Progesterone elevation on the day of hCG trigger has detrimental effect on live birth rate in low and intermediate ovarian responders, but not in high responders
机构：[1]Department of Reproductive Medicine, The First People’s Hospital of Yunnan Province, Kunming, China.门急诊片生殖医学科云南省第一人民医院[2]Reproductive Medical Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.门急诊片生殖医学科云南省第一人民医院
Progesterone elevation (PE) on the day of hCG trigger is associated with decreased pregnancy outcome in fresh cycles. Evidence for this comes from overall patient estimates that mostly ignore different ovarian responses. To compare the impacts of PE on the day of hCG trigger on live birth rates (LBs) in low, intermediate and high ovarian responders and to explore the cut-off value for PE in different populations according to the ovarian response, we retrospectively analyzed a total of 2,351 patients receiving fresh assisted reproduction technology (ART) transfer cycles with GnRH agonist using a long or short protocol. Trend and multivariate logistic regression analyses were performed to identify the cutoff values of PE and to evaluate the effects of PE on LB rates (LBRs) in different ovarian responders. The study found that PE has a detrimental effect on LBRs in low to intermediate ovarian responders rather than in high responders. The cut-off values for PE were 1.0 ng/mL and 2.0 ng/mL for low and intermediate ovarian responders, respectively. The different associations between PE and LBRs according to ovarian response could more accurately predict the prognosis of the IVF cycle and could be used to optimize the treatment of patients undergoing In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI).
基金：
This study was supported by the National Natural Science Foundation of China (No. 81660266). The work was
also supported by the Program of Application and Fundamental Research of Joint Special project of Yunnan
Provincial Science Technology Department & Kunming Medical University [2017FE467(−114)], the Medicine
Academic Leaders Training Program of Yunnan Province (D-201634), the Yunnan Academic leaders and Reserve
Personnel (2017HB041) the Provincial Innovation Team of Human Assisted Reproductive Technology Research,
the First People’s Hospital of Yunnan Province (2017HC009), the National Key Research and Development
Program (2018YFC1002106), and the Program of Application and Fundamental Research of Joint Special project
of Yunnan Provincial Science Technology Department & Kunming Medical University [2018FE001(−302)].
第一作者机构：[1]Department of Reproductive Medicine, The First People’s Hospital of Yunnan Province, Kunming, China.[2]Reproductive Medical Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Reproductive Medicine, The First People’s Hospital of Yunnan Province, Kunming, China.[2]Reproductive Medical Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
推荐引用方式(GB/T 7714)：
Wu Ze,Dong Yunhua,Ma Yanping,et al.Progesterone elevation on the day of hCG trigger has detrimental effect on live birth rate in low and intermediate ovarian responders, but not in high responders[J].SCIENTIFIC REPORTS.2019,9:doi:10.1038/s41598-019-41499-1.
APA：
Wu, Ze,Dong, Yunhua,Ma, Yanping,Li, Yonggang,Li, Lei...&Kang, Xiaomin.(2019).Progesterone elevation on the day of hCG trigger has detrimental effect on live birth rate in low and intermediate ovarian responders, but not in high responders.SCIENTIFIC REPORTS,9,
MLA：
Wu, Ze,et al."Progesterone elevation on the day of hCG trigger has detrimental effect on live birth rate in low and intermediate ovarian responders, but not in high responders".SCIENTIFIC REPORTS 9.(2019)
