机构：[1]Taian Hosp Tradit Chinese Med, Dept Med, Div Tradit Chinese Med, Tai An, Shandong, Peoples R China[2]First Peoples Hosp Yunnan Prov, Dept Med, Div Geriatr, Kunming, Peoples R China云南省第一人民医院[3]Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Med, Div Endocrinol, Jinan 250014, Peoples R China[4]Shandong Univ, Qilu Hosp, Dept Med, Div Endocrinol, Jinan 250014, Peoples R China
Apoptosis of renal proximal tubular epithelial cells (PTECs) plays a vital role in the pathogenesis and progression of diabetic kidney disease (DKD). Calcium dobesilate is a vascular protective compound used for treatment of diabetic retinopathy and chronic venous insufficiency. The aim of this study was to determine whether calcium dobesilate can protect PTECs from glucose- induced apoptosis and the potential mechanism of this effect. It is indicated that high glucose promoted abnormal apoptosis of HK2 cells, which was inhibited by treatment of calcium dobesilate, while Bim expression decreased in response to calcium dobesilate in highglucose- treated HK2 cells. These findings confirmed the therapeutic effects of calcium dobesilate on DKD and emphasized the importance of it as a potentially crucial drug in treatment of DKD.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81670757, 81570742]; Grant for the development of science and technology of Shandong Province [2010GSF10228, 2012GGH11862, 2014GSF118118]; Shandong Provincial Natural Science Foundation of ChinaNatural Science Foundation of Shandong Province [ZR2016HQ26, Y2008C73, ZR2010HM044]; Shandong Provincial Science and Technology Development Program, China [2009GGB14001]; Grant for Excellent Young and Middle-aged Scientists of Shandong Province [2004BS02016]; Grant for the development of science and technology of JiNan City [201602172]; Merck Serono Co., Ltd.
第一作者机构：[1]Taian Hosp Tradit Chinese Med, Dept Med, Div Tradit Chinese Med, Tai An, Shandong, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[3]Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Med, Div Endocrinol, Jinan 250014, Peoples R China[4]Shandong Univ, Qilu Hosp, Dept Med, Div Endocrinol, Jinan 250014, Peoples R China[*1]Department of Medicine Division of Endocrinology Qilu Hospital of Shandong University Shandong University Jinan, 250014 China[*2]Department of Medicine Division of Endocrinology Shandong Provincial Qianfoshan Hospital Shandong University Jinan, 250014 China
推荐引用方式(GB/T 7714)：
Cai Tian,Wu Xiao-yun,Zhang Xiao-qian,et al.Calcium Dobesilate Prevents Diabetic Kidney Disease by Decreasing Bim and Inhibiting Apoptosis of Renal Proximal Tubular Epithelial Cells[J].DNA AND CELL BIOLOGY.2017,36(4):249-255.doi:10.1089/dna.2016.3276.
APA：
Cai, Tian,Wu, Xiao-yun,Zhang, Xiao-qian,Shang, Hong-xia,Zhang, Zhong-wen...&Dong, Jian-jun.(2017).Calcium Dobesilate Prevents Diabetic Kidney Disease by Decreasing Bim and Inhibiting Apoptosis of Renal Proximal Tubular Epithelial Cells.DNA AND CELL BIOLOGY,36,(4)
MLA：
Cai, Tian,et al."Calcium Dobesilate Prevents Diabetic Kidney Disease by Decreasing Bim and Inhibiting Apoptosis of Renal Proximal Tubular Epithelial Cells".DNA AND CELL BIOLOGY 36..4(2017):249-255
