机构：[1]Genetic Diagnosis Center, Yunnan Provincial Key Laboratory For Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China,门急诊片医学遗传科云南省第一人民医院[2]Lab of Molecular Genetics of Aging & Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China
To evaluate the association of the TP53 codon 72 (rs 1042522) alone or in combination with HDM2 SNP309 (rs 2279744) polymorphisms with human infertility and IVF outcome, we collected 1450 infertility women undergoing their first controlled ovarian stimulation for IVF treatment and 250 fertile controls in the case-control study. Frequencies, distribution, interaction of genes, and correlation with infertility and IVF outcome of clinical pregnancy were analyzed. We found a statistically significant association between TP53 codon 72 polymorphism and IVF outcome (52.10% vs. 47.40%, OR =0.83, 95%CI:0.71-0.96, p = 0.01). No significant difference was shown between TP53 codon 72, HDM2 SNP309 polymorphisms, human infertility, and between the combination of two genes polymorphisms and the clinical pregnancy outcome of IVF. The data support C allele as a protective factor for IVF pregnancy outcome. Further researches should be focused on the mechanism of these associations.
基金：
The study was supported by the State
Key Laboratory of Genetics Resources and
Evolution, grant GREKF10-07, and by the
Technological Leading Talent of Industries in
Yunnan Province, grant L201201.
第一作者机构：[1]Genetic Diagnosis Center, Yunnan Provincial Key Laboratory For Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Chan Ying,Zhu Baosheng,Jiang Hongguo,et al.Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome[J].PLOS ONE.2016,11(11):doi:10.1371/journal.pone.0167147.
APA：
Chan, Ying,Zhu, Baosheng,Jiang, Hongguo,Zhang, Jinman,Luo, Ying&Tang, Wenru.(2016).Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome.PLOS ONE,11,(11)
MLA：
Chan, Ying,et al."Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome".PLOS ONE 11..11(2016)
