机构：[1]Department of Clinical Laboratory, Yunnan Provincial First People’s Hospital, Kunming, Yunnan 650032, China医技片检验科云南省第一人民医院[2]Institute of Clinical and Basic Medical Sciences, Yunnan Provincial First People’s Hospital, Kunming, Yunnan 650032, China云南省第一人民医院[3]Department of Hematology, Yunnan Provincial First People’s Hospital, Kunming, Yunnan 650032, China内科片血液内科云南省第一人民医院
Macrophages have emerged as a key player in tumor biology. However, their number and phenotype in human bone marrow of biopsy (BMB) samples of chronic myeloid leukemia (CML) and their association with disease progression from an initial chronic phase (CP) to accelerated phase (AP) to advanced blast phase (BP) are still unclear. BMB samples from 127 CML patients and 30 patients with iron-deficiency anemia (IDA) as control group were analyzed by immunohistochemistry. The expression levels of CD68, CD163, and CD206 in BMB samples of CML patients were significantly higher than those in the patients of control group (p < 0.01), and we observed that their positive expression was gradually elevated during the transformation of CML-CP to AP to BP (p < 0.01). However, the expressions of CD68, CD163, and CD206 in released group were downregulated and contrasted to these in control group; there exists statistical significance (p < 0.01). The percentage ratio of CD163 and CD206 to CD68 was pronounced to be increasing from CML-CP to AP to BP (p < 0.01). Hence, the higher proportion of CD68(+), CD163(+) and CD206(+) macrophages in BMB samples can be considered a key factor for disease progression of CML patients. Targeting macrophages, especially the M2 phenotype may help in designing therapeutic strategies for CML.
基金：
National Science Funding of China (NSFC) [31460298]; Basic Research on Application of Joint Special Funding of Science and Technology Department of Yunnan Province, Kunming Medical University [2014FZ070, 2014FB092]
基金编号：314602982014FZ070 2014FB092
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2015]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Clinical Laboratory, Yunnan Provincial First People’s Hospital, Kunming, Yunnan 650032, China[2]Institute of Clinical and Basic Medical Sciences, Yunnan Provincial First People’s Hospital, Kunming, Yunnan 650032, China
通讯作者：
通讯机构：[2]Institute of Clinical and Basic Medical Sciences, Yunnan Provincial First People’s Hospital, Kunming, Yunnan 650032, China
推荐引用方式(GB/T 7714)：
Song Jian-Xin,Dian Zi-Jin,Wen Yan,et al.Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML[J].BIOMED RESEARCH INTERNATIONAL.2016,2016:doi:10.1155/2016/8086398.
APA：
Song, Jian-Xin,Dian, Zi-Jin,Wen, Yan,Mei, Fen,Li, Rui-Wei&Sa, Ya-Lian.(2016).Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML.BIOMED RESEARCH INTERNATIONAL,2016,
MLA：
Song, Jian-Xin,et al."Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML".BIOMED RESEARCH INTERNATIONAL 2016.(2016)
