Osteopontin and Integrin alpha v beta 3 Expression during the Implantation Window in IVF Patients with Elevated Serum Progesterone and Oestradiol Level
机构：[1]Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, The First Peopleʼs Hospital of Yunnan Province, Kunming, Peopleʼs Republic of China门急诊片生殖医学科医学遗传科云南省第一人民医院[2]Department of Pathology, The First Peopleʼs Hospital of Yunnan Province, Kunming, Peopleʼs Republic of China[3]Institute of Molecular and Clinical Medicine, Kunming Medical University, Chengong New District, Kunming, Peopleʼs Republic of China[4]Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third Hospital, Haidian District, Beijing, Peopleʼs Republic of China
Background: To explore whether endometrial receptivity is determined by osteopontin (OPN) and integrin avp3 expression in women with elevated serum progesterone (P) and/or oestradiol (E2) who are undergoing in vitro fertilisation (IVF). Methods: According to serum hormone levels on the day of I-ICC administration, 33 infertile women were divided into 3 groups: the high E2, high P, and high E2 and P groups. The control group included 11 fertile, healthy women. Endometrial biopsy was performed on ovulation day + 7 to + 8 for all study participants, and the mRNA and protein expression levels of OPN and integrin aV beta 13 were analyzed, Result: No statistically significant differences regarding OPN and integrin avp3 expression were found between infertile patients in the high P. high E2, high E2 and P and control groups. There was no significant correlation between OPN and integrin avp3 staining intensity during the implantation window biopsy in any of the groups studied, ``Conclusion: Endometrial OPN and integrant avp3 expression/co-expression is not impaired during the window of implantation in patients with high P. high E2, or high E2 and P levels. The clinical value of assessing endometrial receptivity with OPN and integrin avp3 seems to be uncertain,
第一作者机构：[1]Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, The First Peopleʼs Hospital of Yunnan Province, Kunming, Peopleʼs Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, The First Peopleʼs Hospital of Yunnan Province, Kunming, Peopleʼs Republic of China[4]Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third Hospital, Haidian District, Beijing, Peopleʼs Republic of China[*1]Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third Hospital, No. 49 North Huayuan Road, Haidian District Beijing 10091, Peopleʼs Republic of China[*2]Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, The First Peopleʼs Hospital of Yunnan Province, No. 157 Jin Bi Road Kunming 650032, Peopleʼs Republic of China
推荐引用方式(GB/T 7714)：
Zhenlin He,Yanping Ma,L. Li,et al.Osteopontin and Integrin alpha v beta 3 Expression during the Implantation Window in IVF Patients with Elevated Serum Progesterone and Oestradiol Level[J].GEBURTSHILFE UND FRAUENHEILKUNDE.2016,76(6):709-717.doi:10.1055/s-0041-111697.
APA：
Zhenlin He,Yanping Ma,L. Li,J. Liu,H. Yang...&J. Qiao.(2016).Osteopontin and Integrin alpha v beta 3 Expression during the Implantation Window in IVF Patients with Elevated Serum Progesterone and Oestradiol Level.GEBURTSHILFE UND FRAUENHEILKUNDE,76,(6)
MLA：
Zhenlin He,et al."Osteopontin and Integrin alpha v beta 3 Expression during the Implantation Window in IVF Patients with Elevated Serum Progesterone and Oestradiol Level".GEBURTSHILFE UND FRAUENHEILKUNDE 76..6(2016):709-717
