机构：[1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China,[2]Department of Clinical Laboratory, The People’s Hospital of LuXi County in Yunnan Province, Yunnan, China,[3]Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, Shanghai, China[4]Department of Clinical Laboratory, The First People’s Hospital of Yunnan Province, Yunnan, China医技片检验科云南省第一人民医院
Hepatitis C was the most popular chronic infectious liver disease worldwide. It was identified that Hepatitis C virus (HCV) infection could lead to mitochondrial dysfunction, though the mechanism was not fully understood. To investigate whether mtDNA copy number could be affected by HCV infection and be associated with clinical features of HCV patients, mtDNA copy numbers were analyzed in 242 patients with HCV infection and 226 matched control samples. The results suggested that mtDNA copy numbers significantly decreased in HCV patients (68.80 +/- 3.33) than in control samples (81.54 +/- 4.50) (p = 0.022). When males/females were separated from total patients to compare mtDNA copy numbers with gender matched controls, mtDNA copy numbers still significantly decreased in male HCV patients (p = 0.002). Further analysis indicated that level of high-density lipoprotein cholesterol (HDL-C) was negatively correlated with mtDNA copy numbers in total HCV patients (r = -0.128, p = 0.047), and this correlation was more significant in male HCV patients (r = -0.266, p = 0.030). Intriguingly, aspartate amino-transferase (AST) showed positive correlation with mtDNA copy numbers (r = 0.260, p = 0.034) in male HCV patients. Our results indicated that mtDNA copy numbers depleted and correlated with clinical features in male HCV patients.
基金：
This study was supported by the National Natural Science Foundation of
China (31460289, 81260248) and Training Program Foundation
for Talent of Kunming University of Science and Technology
(KKSY201226148).
第一作者机构：[1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China,[*1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
通讯作者：
通讯机构：[1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China,[*1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
推荐引用方式(GB/T 7714)：
Zhang A-Mei,Ma Ke,Song Yuzhu,et al.Mitochondrial DNAs decreased and correlated with clinical features in HCV patients from Yunnan, China[J].MITOCHONDRIAL DNA PART A.2016,27(4):2516-2519.doi:10.3109/19401736.2015.1036255.
APA：
Zhang, A-Mei,Ma, Ke,Song, Yuzhu,Feng, Yue,Duan, Haiping...&Xia, Xueshan.(2016).Mitochondrial DNAs decreased and correlated with clinical features in HCV patients from Yunnan, China.MITOCHONDRIAL DNA PART A,27,(4)
MLA：
Zhang, A-Mei,et al."Mitochondrial DNAs decreased and correlated with clinical features in HCV patients from Yunnan, China".MITOCHONDRIAL DNA PART A 27..4(2016):2516-2519
