Objective: To fully explore clinical effect of rotational atherectomy and drug treatment for left main coronary artery calcification. Method: 1000 patients with left main coronary artery calcified stenotic lesions treated in ten hospitals in 2014 were included in the study. First, coronary rotational atherectomy and drug eluting stent (DES) implantation were adopted for treatment, and all patients were observed on return visits fora period of 12 months postoperative. Results: Of 1000 patients, 984 had a successful operation, which is a 98.4%. success rate. In addition, 16 patients had Various degrees of postoperative adverse reactions and gradually improved after follow-up treatment. During the follow-up period, I patient was lost due to, sudden cardiac death, and 21 patients suffered from angina and were hospitalitezed again. Conclusion: The results demonstrate that coronary artery rotational atherectomy and drug stent implantation surgery offer high safety for serious calcified stenotic lesion of left main coronary artery, with good clinical effects and high clinical application value.