Positivity and incidence of human papillomavirus in women attending gynecological department of a major comprehensive hospital in Kunming, China 2012-2014
机构：[1]Kirby Institute, University of New South Wales, New South Wales, Australia[2]Department of Clinical Laboratories, The First People’s Hospital of Yunnan, Province, Kunming, Yunnan, China[3]Department of Clinical Laboratories, The Kunhua Affiliated Hospital, Kunming, University of Science and Technology, Kunming, Yunnan, China[4]Yunan Kunming Blood Center, Kuming, Yunnan, China[5]Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China[6]Huainan First People’s Hospital, Huainan, Anhui, China
HPV DNA testing is receiving increasing popularity in cervical cancer screening. There is a lack of universal guidelines on HPV testing. Our study aimed to assess age-specific and year-on-year trend of HPV positivity and incidence and HPV retesting among 26,457 individual women attending the gynecological department at the First People's Hospital of Yunnan Province (FPHY) who had an HPV testing between January 1, 2012 and December 31, 2014. HPV 16, HPV 52, and cp8304 ranked among top 5 with regard to positivity in each year and overall incidence. The positivity of various HPV types peaked among women aged 15-19 years, then sharply decreased with age, stabilized among women aged 25-49 years and then surged again among women aged 50 years and older. The positivity of high-risk (HR) HPV types, including HPV 16, 18, 31, 33, 56 and 58, were on the rise during the time period (P<0.05 for all). HR HPV types tended to be more likely to persist than LR HPV types (P<0.05). Additionally, the incidence rate for any HR HPV type was also significantly higher than that for any LR HPV type (42.8 vs. 12.6 per 100 person-years, P<0.001). The majority (57.3-77.5%) of women detected with HR HPV types did not retest within 12 months. Clinical guidelines on HPV DNA testing are needed and education, and counseling about HPV infection and its implications for women detected with HPV at clinical settings, are warranted. J. Med. Virol. 88:703-711, 2016. (c) 2015 Wiley Periodicals, Inc.
基金：
Australian National Health and Medical
Research Commission (NHMRC); Grant number: APP1092621;
Grant sponsor: Natural Science Foundation of China (NSFC);
Grant number: 81100377; Grant sponsor: Applied Basic Research
Foundation of Yunnan Province; Grant number: 2013FB203
第一作者机构：[1]Kirby Institute, University of New South Wales, New South Wales, Australia[*1]Kirby Institute, University of New South Wales, Room 660, Wallace Wurth Building, New South Wales, Sydney, Australia, 2052.
共同第一作者：
通讯作者：
通讯机构：[1]Kirby Institute, University of New South Wales, New South Wales, Australia[2]Department of Clinical Laboratories, The First People’s Hospital of Yunnan, Province, Kunming, Yunnan, China[3]Department of Clinical Laboratories, The Kunhua Affiliated Hospital, Kunming, University of Science and Technology, Kunming, Yunnan, China[*1]Kirby Institute, University of New South Wales, Room 660, Wallace Wurth Building, New South Wales, Sydney, Australia, 2052.[*2]Department of Clinical Laboratories, The First People’s Hospital of Yunnan Province, Kunming, 157 Jinbi Rd, Xishan, Kunming, Yunnan, China 650032.
推荐引用方式(GB/T 7714)：
Zou Huachun,Sun Yi,Zhang Guiqian,et al.Positivity and incidence of human papillomavirus in women attending gynecological department of a major comprehensive hospital in Kunming, China 2012-2014[J].JOURNAL OF MEDICAL VIROLOGY.2016,88(4):703-711.doi:10.1002/jmv.24377.
APA：
Zou, Huachun,Sun, Yi,Zhang, Guiqian,Tu, Yuanquan,Meng, Xiaojun...&Gao, Yuhong.(2016).Positivity and incidence of human papillomavirus in women attending gynecological department of a major comprehensive hospital in Kunming, China 2012-2014.JOURNAL OF MEDICAL VIROLOGY,88,(4)
MLA：
Zou, Huachun,et al."Positivity and incidence of human papillomavirus in women attending gynecological department of a major comprehensive hospital in Kunming, China 2012-2014".JOURNAL OF MEDICAL VIROLOGY 88..4(2016):703-711
