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No association between Y chromosomal haplogroups and severe acne in the Han Chinese population

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收录情况： ◇ SCIE

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机构： [1]Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming, China [2]KIZ/CUHK Joint Laboratory of Bioresources and MolecularResearch in Common Diseases, Kunming, China [3]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences,Kunming, China [4]Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University,Kunming, China [5]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China [6]Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China [7]Department of Dermatology, Xiangya Hospital Central South University,Changsha, China [8]Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China [9]Department of Dermatology, The Second Affiliated Hospital of ZhejiangUniversity School of Medicine, Hangzhou, China [10]Department of Dermatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China [11]Department ofDermatology, Peking University Third Hospital, Beijing, China [12]Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, China [13]Department ofDermatology, Qilu Hospital of Shandong University, Jinan, China [14]Department of Dermatology, Changshu NO.1 People’s Hospital, Changshu, China [15]Department ofDermatology, Dalian Dermatosis Hospital, Dalian, China [16]Department of Dermatology, First people’s Hospital of Yunnan Province, Kunming, China [17]Yuxi Lianyuan Hospital,Yuxi, China [18]Department of Dermatology, Kaiyuan People’s Hospital, Kaiyuan, China [19]Winona Dermo-Cosmetology Center, Kunming, China

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摘要：

Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.

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出版当年[2014]版：

大类 | 3 区生物

小类 | 4 区遗传学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区遗传学

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出版当年[2013]版：

Q3 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 2.6 最新[2023版] 2.6 最新五年平均 2.526 出版当年[2013版] 2.411 出版当年五年平均 2.365 出版前一年[2012版] 2.462 出版后一年[2014版]

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第一作者机构： [1]Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming, China

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通讯作者：

通讯机构： [1]Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming, China [2]KIZ/CUHK Joint Laboratory of Bioresources and MolecularResearch in Common Diseases, Kunming, China [3]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences,Kunming, China [4]Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University,Kunming, China [*1]Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province, Kunming 650032, China. [*2]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

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