机构：[1]Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China[2]Department of Medicine and Molecular Biological Center, Kunming University, Kunming 650118, PR China[3]Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, PR China[4]First People’s Hospital of Yunnan Province, Kunming 650032, PR China云南省第一人民医院
In our previous studies, geraniin was reported to have a preventive effect in the rat model of tretinoin-induced osteoporosis. However, whether geraniin exhibits an inhibitory effect on bone resorption or on MMP-9 expression is not yet known. We present here our novel findings from in vitro experiments that geraniin (a) decreases the number of mature osteoclasts and pre-osteoclast in cultures, (b) reduces the osteoclastic fusion index, and (c) inhibits the resorption areas and resorption pits. We also report that geraniin suppresses the mRNA and protein expression levels of MMP-9. These results demonstrate that geraniin has an inhibitory effect on the bone-absorption ability of osteoclasts in vitro, and the mechanisms may be closely associated with the downregulation of mRNA and protein expression of MMP-9. (c) 2012 Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30660212, 81160401, 81060361]; Natural Science Foundation of Yunnan Province, ChinaNatural Science Foundation of Yunnan Province [2008CC009, 2004C0044 M, 2012fa002]; Natural Science Foundation of Kunming City, China [10S090202]
第一作者机构：[1]Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China
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推荐引用方式(GB/T 7714)：
He Bo,Hu Min,Li Shu-De,et al.Effects of geraniin on osteoclastic bone resorption and matrix metalloproteinase-9 expression[J].BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.2013,23(3):630-634.doi:10.1016/j.bmcl.2012.12.005.
APA：
He, Bo,Hu, Min,Li, Shu-De,Yang, Xue-Ting,Lu, Yi-Qin...&Shen, Zhi-Qiang.(2013).Effects of geraniin on osteoclastic bone resorption and matrix metalloproteinase-9 expression.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23,(3)
MLA：
He, Bo,et al."Effects of geraniin on osteoclastic bone resorption and matrix metalloproteinase-9 expression".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23..3(2013):630-634
