机构：[1]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China,[2]The Second People’s Hospital of Yunnan Province, Kunming, China,[3]Yunnan Center for Disease Control and Prevention, Kunming, China,[4]The First People’s Hospital of Yunnan Province, Kunming, China云南省第一人民医院[5]The Graduate School of the Chinese Academy of Sciences, Beijing, China
Background: Co-infection with HIV and HCV and/or HBV is highly prevalent in intravenous drug users (IDUs). Because of the proximity to the "Golden Triangle'', HIV prevalence among the IDUs is very high in the China-Myanmar border region. However, there are few studies about co-infection with HIV and HCV and/or HBV, especially in the region that belongs to Myanmar. Methods: 721 IDUs, including 403 Chinese and 318 Burmese, were investigated for their HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) serological status. Statistical analysis was performed to evaluate the differences of the epidemic situation between the Chinese IDUs and the Burmese IDUs. Results: Among the Chinese IDUs and the Burmese IDUs, HCV infection was the most prevalent (69.0% vs 48.1%, P<0.001), followed by HBV (51.6% vs 43.1%, P<0.05) and HIV (33.7% vs 27.0%, P>0.05). Besides, there were more HIV-HBV co-infected IDUs (20.1% vs 11.3%, P<0.005), and HIV-HCV co-infected IDUs (31.8% vs 23.9%, P<0.05) in China than in Myanmar, as well as HIV-HBV-HCV triple infection (19.1% vs 10.4%, P<0.005). Conclusion: Co-infection with HIV and HCV and/or HBV is highly prevalent among the IDUs in the China-Myanmar border region. The HIV epidemic appears to be in a downward trend, compared with previous reports. However, all infections were more prevalent among the Chinese IDUs than among the Burmese.
基金：
National Basic Research Program of China (2006CB504302, 2009CB522306), the National Natural
Science Foundation of China (30671960, U0832601), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX10004-902, 2009ZX09501-
029, 2008ZX10001-002, 2008ZX10001-015), and the HIV/AIDS Asia Regional Program.
第一作者机构：[1]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China,[5]The Graduate School of the Chinese Academy of Sciences, Beijing, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Yan-Heng,Liu Feng-Liang,Yao Zhi-Hong,et al.Comparison of HIV-, HBV-, HCV- and Co-Infection Prevalence between Chinese and Burmese Intravenous Drug Users of the China-Myanmar Border Region[J].PLOS ONE.2011,6(1):doi:10.1371/journal.pone.0016349.
APA：
Zhou, Yan-Heng,Liu, Feng-Liang,Yao, Zhi-Hong,Duo, Lin,Li, Hong...&Zheng, Yong-Tang.(2011).Comparison of HIV-, HBV-, HCV- and Co-Infection Prevalence between Chinese and Burmese Intravenous Drug Users of the China-Myanmar Border Region.PLOS ONE,6,(1)
MLA：
Zhou, Yan-Heng,et al."Comparison of HIV-, HBV-, HCV- and Co-Infection Prevalence between Chinese and Burmese Intravenous Drug Users of the China-Myanmar Border Region".PLOS ONE 6..1(2011)
