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Correlation of Expression of Human Arrest-Defective-1 (hARD1) Protein With Breast Cancer

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收录情况： ◇ SCIE

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机构： [1]Laboratory of Biochemistry and Molecular Biology, School of Life Science, Yunnan University, Kunming, China [2]Department of Pathology, First Peoples Hospital of Yunnan Province, Kunming, China

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关键词： hARD1 Breast cancer MCF-7 Cell proliferation

摘要：

Human arrest-defective-1 (hARD1) was reported to be important in regulating cell cycle and promoting lung cancer cell proliferation. Here we have investigated the correlation between hARD1 and breast cancer. Analysis with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry (FCM) demonstrated that overexpression of hARD1 was associated with increased proliferation of MCF-7 cell, a human breast cancer cell line. Western blotting and immunohistochemical staining assay showed that hARD1 presented higher in breast cancer tissue than the adjacent tissue; accumulation of hARD1 protein was higher in 86% (37/43) of breast cancer, far more than noncancer samples. Our results suggest that hARD1 might play an important role in breast cancer carcinogenesis.

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出版当年[2009]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2008]版：

Q3 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 1.8 最新[2023版] 2.1 最新五年平均 1.976 出版当年[2008版] 2.28 出版当年五年平均 2.106 出版前一年[2007版] 2.105 出版后一年[2009版]

第一作者：

第一作者机构： [1]Laboratory of Biochemistry and Molecular Biology, School of Life Science, Yunnan University, Kunming, China

通讯作者：

通讯机构： [1]Laboratory of Biochemistry and Molecular Biology, School of Life Science, Yunnan University, Kunming, China [*1]Laboratory of Biochemistry and Molecular Biology School of Life Sciences Yunnan University 650091 Kunming, China

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