机构：[1]Division of Gastroenterology/Hepatology, Department of Medicine, University of Kansas Medical Center, 4035 Delp, MS 1023, Kansas City, KS 66160, USA[2]The First People’s Hospital of Yunnan Province, Kunming, China云南省第一人民医院[3]Gunagzhou Blood Center, Guangzhou City, Guangdong Province, China[4]Public Health Laboratories, New Hampshire Department of Health and Human Services, Concord, NH, USA[5]Department of Zoology, Oxford University, Oxford, UK[6]Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan[7]Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi-Ken, Japan[8]Institut National de Sante´ Publique du Quebec, Laboratoire de Sante´ Publique du Quebec, Sainte-Anne-de-Bellevue, Quebec, Canada
Five hepatitis C virus (HCV) complete genome sequences (Th846, 537796, QC227, OC216 and QC99) from a blood donor in Thailand and three Asian immigrants and one Caucasian in North America were determined. Phylogenetically, they represent the first complete genomes for subtypes 6c, 6l, 6o, 6p and 6q, respectively. Similarity analysis showed no evidence of inter- or intrasubtype recombination. Further analysis in conjunction with partial sequences from the Los Alamos HCV database led to the identification of other closely related isolates from south-eastern Asia or immigrants from that region. However, Th846 did not cluster with any reference sequence and is the sole isolate of subtype 6c reported so far. This study completes the full genome sequencing of all 17 assigned HCV genotype 6 subtypes (6a-6q). The utility of this panel of complete sequences for accurate detection and classification of infection, and for estimating the origin of this genotype of HCV, is discussed.
基金：
This work was supported by NIH grants 5 P20 RR016443-04 and
CA063640.
第一作者机构：[1]Division of Gastroenterology/Hepatology, Department of Medicine, University of Kansas Medical Center, 4035 Delp, MS 1023, Kansas City, KS 66160, USA
通讯作者：
推荐引用方式(GB/T 7714)：
Ling Lu,Chunhua Li,Yongshui Fu,et al.Complete genomes of hepatitis C virus (HCV) subtypes 6c, 5l, 6o, 6p and 6q: completion of a full panel of genomes for HCV genotype 6[J].JOURNAL OF GENERAL VIROLOGY.2007,88:1519-1525.doi:10.1099/vir.0.82820-0.
APA：
Ling Lu,Chunhua Li,Yongshui Fu,Fengxiang Gao,Oliver G. Pybus...&Donald Murphy.(2007).Complete genomes of hepatitis C virus (HCV) subtypes 6c, 5l, 6o, 6p and 6q: completion of a full panel of genomes for HCV genotype 6.JOURNAL OF GENERAL VIROLOGY,88,
MLA：
Ling Lu,et al."Complete genomes of hepatitis C virus (HCV) subtypes 6c, 5l, 6o, 6p and 6q: completion of a full panel of genomes for HCV genotype 6".JOURNAL OF GENERAL VIROLOGY 88.(2007):1519-1525
