机构：[1]Institute of Neuroscience, Basic Medical College, Kunming Medical University, Kunming, China,[2]Department ofNeurosurgery, Shanghai Jiao Tong University Affiliated 6th People’s Hospital, Shanghai, China,[3]Monash Immunology andStem Cell Laboratories (MISCL), Monash University, Clayton, VIC, Australia,[4]Key Laboratory of Human DiseasesComparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS) and Comparative Medicine Centre, Peking Union Medical College (PUMC), Beijing, China,[5]Yunnan Provincial KeyLaboratory for Birth Defects and Genetic Diseases, Department of Medical Genetics, The First People’s Hospital of YunnanProvince, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China门急诊片医学遗传科云南省第一人民医院
Cytochrome c oxidase subunit Va (COX5A) is involved in maintaining normal mitochondrial function. However, little is known on the role of COX5A in the development and progress of Alzheimer’s disease (Martinez-Losa et al., 2018). In this study, we established and characterized the genomic profiles of genes expressed in the hippocampus of Senescence-Accelerated Mouse-prone 8 (SAMP8) mice, and revealed differential expression of COX5A among 12-month-aged SAMP8 mice and 2-month-aged SAMP8 mice. Newly established transgenic mice with systemic COX5A overexpression (51% increase) resulted in the improvement of spatial recognition memory and hippocampal synaptic plasticity, recovery of hippocampal CA1 dendrites, and activation of the BDNF/ERK1/2 signaling pathway in vivo. Moreover, mice with both COX5A overexpression and BDNF knockdown showed a poor recovery in spatial recognition memory as well as a decrease in spine density and branching of dendrites in CA1, when compared to mice that only overexpressed COX5A. In vitro studies supported that COX5A affected neuronal growth via BDNF. In summary, this study was the first to show that COX5A in the hippocampus plays a vital role in aging-related cognitive deterioration via BDNF/ERK1/2 regulation, and suggested that COX5A may be a potential target for anti-senescence drugs..
基金：
the National Natural Science Foundation of China (grant numbers 81960210, 81701212, 81960238 and 81502377), Foundation of Science and Technology Innovative Team Building of Kunming Medical University (grant number CXTD201807).
第一作者机构：[1]Institute of Neuroscience, Basic Medical College, Kunming Medical University, Kunming, China,
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推荐引用方式(GB/T 7714)：
Yan-Bin Xiyang,Ruan Liu,Xu-Yang Wang,et al.COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging via the BDNF/ERK1/2 Signaling Pathway(Open Access)[J].FRONTIERS IN AGING NEUROSCIENCE.2020,12:doi:10.3389/fnagi.2020.00215.
APA：
Yan-Bin Xiyang,Ruan Liu,Xu-Yang Wang,Shan Li,Ya Zhao...&Jie Zhang.(2020).COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging via the BDNF/ERK1/2 Signaling Pathway(Open Access).FRONTIERS IN AGING NEUROSCIENCE,12,
MLA：
Yan-Bin Xiyang,et al."COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging via the BDNF/ERK1/2 Signaling Pathway(Open Access)".FRONTIERS IN AGING NEUROSCIENCE 12.(2020)
