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The FOXK1-CCDC43 axis promotes the invasion and metastasis of colorectal cancer cells(Open Access)

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资源类型：
Pubmed体系：
作者：
Jing Wang[a] * ; Guangnan Liu[a] ; Mengwei Liu[a] ; Li Xiang[b] ; Yizhi Xiao[a] ; Huiqiong Zhu[a] ; Xiaosheng Wu[a] ; Ying Peng[a] ; Wenjing Zhang[c] ; Ping Jiang[a] ; Aimin Li[a] ; Qingzhen Nan[a] ; Ye Chen[a] ; Chudi Chen[a] ; Tianming Cheng[a] ; Side Liu[a,b,*1] ; Jide Wang[a,b,*1] ;
机构： [a]Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, [b]Department of Gastroenterology, Longgang District People’s Hospital, Shenzhen, [c]Department of Medical Oncology, the First people’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, China
出处：
DOI： 10.1159/000495924
ISSN：

关键词： CCDC43 Colorectal cancer Epithelial-mesenchymal transition FOXK1 Invasion Metastasis

摘要：
Background/Aims: The CCDC43 gene is conserved in human, rhesus monkey, mouse and zebrafish. Bioinformatics studies have demonstrated the abnormal expression of CCDC43 gene in colorectal cancer (CRC). However, the role and molecular mechanism of CCDC43 in CRC remain unknown. Methods: The functional role of CCDC43 and FOXK1 in epithelial-mesenchymal transition (EMT) was determined using immunohistochemistry, flow cytometry, western blot, EdU incorporation, luciferase, chromatin Immunoprecipitation (ChIP) and cell invasion assays. Results: The CCDC43 gene was overexpressed in human CRC. High expression of CCDC43 protein was associated with tumor progression and poor prognosis in patients with CRC. Moreover, the induction of EMT by CCDC43 occurred through TGF-β signaling. Furthermore, a positive correlation between the expression patterns of CCDC43 and FOXK1 was observed in CRC cells. Promoter assays demonstrated that FOXK1 directly bound and activated the human CCDC43 gene promoter. In addition, CCDC43 was necessary for FOXK1- mediated EMT and metastasis in vitro and vivo. Taken together, this work identified that CCDC43 promoted EMT and was a direct transcriptional target of FOXK1 in CRC cells. Conclusion: FOXK1-CCDC43 axis might be helpful to develop the drugs for the treatment of CRC. © 2018 The Author(s). Published by S. Karger AG, Basel.

基金：
This study was supported by grants from the National Natural Science Funds of China (grant numbers 81672875 & 81772964), ‘President Foundation of Nanfang Hospital, Southern Medical University’ (grant numbers 2012B009, 2013Z007), and high-level topicmatching funds of Nanfang Hospital (grant numbers 201347 and G201227). Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University; Guangzhou Pilot Project of Clinical and Translational Research Center (early gastrointestinal cancer, grant number 7415696196402).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 生物
小类 | 1 区 生理学 3 区 细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构： [a]Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou,
通讯作者：
通讯机构： [a]Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, [b]Department of Gastroenterology, Longgang District People’s Hospital, Shenzhen, [*1]Department of Digestive Medicine, Nanfang Hospital, Southern Medical University Guangzhou, 510515, Guangdong Province (China)
推荐引用方式(GB/T 7714)：
Jing Wang,Guangnan Liu,Mengwei Liu,et al.The FOXK1-CCDC43 axis promotes the invasion and metastasis of colorectal cancer cells(Open Access)[J].Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.2018,51(6):2547-2563.doi:10.1159/000495924.
APA：
Jing Wang,Guangnan Liu,Mengwei Liu,Li Xiang,Yizhi Xiao...&Jide Wang.(2018).The FOXK1-CCDC43 axis promotes the invasion and metastasis of colorectal cancer cells(Open Access).Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,51,(6)
MLA：
Jing Wang,et al."The FOXK1-CCDC43 axis promotes the invasion and metastasis of colorectal cancer cells(Open Access)".Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 51..6(2018):2547-2563

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