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重症肺囊虫性肺炎的药物治疗方案调整

Adjustment of drug treatment regimens for critical patients with pneumocystis carinii pneumonia

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机构: [1]江西省肿瘤医院药剂科,南昌330029 [2]浙江省杭州市妇产科医院药剂科,杭州310008 [3]云南省曲靖市第一人民医院药剂科,云南曲靖655000 [4]上海交通大学医学院附属瑞金医院呼吸科,上海200025 [5]上海交通大学医学院附属瑞金医院药剂科,上海200025
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关键词: Clinical pharmacists Drug treatment regimens Immunodeficiency Pneumocytis carinii Pneumonia

摘要:
Objective: To investigate the drug treatment regimens for critical patients with pneumocytis carinii pneumonia (PCP). Methods: Through direct involvement of clinical pharmacists in the whole drug treatment of 2 immonosuppressed patients, the drug treatment regimens for critical patients with PCP were adjusted, and therapeutic drug efficacy was evaluated and adverse drug reactions were closely monitored in the process. Results: The initial anti-infection treatment of immonosuppressed patients with pulmonary infection should cover PCP. When patients were unable to tolerate high doses of sulfamethodxazole-trimethoprim (SMZ-TMP) or initial treatment with SMZ-TMP was invalid, the combination of SMZ-TMP with caspofungin could be recommended to treat critical PCP. Conclusion: Combination of SMZ-TMP with caspofungin for the treatment of severe PCP had the advantages of faster response, better clinical efficacy, and more importantly, lower incidence of adverse drug reactions. © 2018 Publishing House of Pharmaceutical Care and Research. All rights reserved.

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第一作者机构: [1]江西省肿瘤医院药剂科,南昌330029
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