机构：[a]Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicing, Kunming University of Science and Technology, Kunming, Yunnan, China[b]Department of Pharmacy, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China医技片药学部云南省第一人民医院
Background: The aim of the meta-analysis was to derive a more precise assessment of the association between p16 promoter methylation and thyroid cancer risk. Materials and Methods: The PubMed, Web of Science databases and Chinese CNKI were searched for relevant articles. Ultimately, seventeen case-control studies were included with a total of 804 thyroid cancer cases and 487 controls analysis by R Software (R version 3.1.2) including meta. Crude odds ratios with 95% confidence intervals were calculated using the random-effects model which were used to assess the strength of relationship between p16 methylation and lung carcinogenesis. Funnel plots were carried out to evaluate publication bias. Results: The meta-analysis results showed that the frequency of p16 promoter methylation in cancer tissue/blood was significantly higher than that normal tissue/blood (OR=5.46, 95%CI 3.12-9.55, P<0.0001) by random effects model with small heterogeneity. Conclusions: Thus, p16 promoter methylation may be associated with thyroid cancer risk.
基金：
National Science Foundation of China (No.81260501, U1202221, U1132604).
语种：
外文
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[a]Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicing, Kunming University of Science and Technology, Kunming, Yunnan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wu W,Yang S.-F,Liu F.-F,et al.Association between P16 promoter methylation and thyroid cancer risk: A meta-analysis(Open Access)[J].Asian Pacific Journal of Cancer Prevention.2015,16(16):doi:10.7314/APJCP.2015.16.16.7111.
APA：
Wu, W,Yang, S.-F,Liu, F.-F&Zhang, J.-H.(2015).Association between P16 promoter methylation and thyroid cancer risk: A meta-analysis(Open Access).Asian Pacific Journal of Cancer Prevention,16,(16)
MLA：
Wu, W,et al."Association between P16 promoter methylation and thyroid cancer risk: A meta-analysis(Open Access)".Asian Pacific Journal of Cancer Prevention 16..16(2015)
