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miR-3622a promotes proliferation and invasion of bladder cancer cells by downregulating LASS2.

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机构： [1]Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Institute of Urology, Kunming 650101, China [2]Department of Urology, The First People's Hospital of Longquanyi District, Chendu 610000, China

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As a tumor metastasis suppressor gene, LASS2 has been found to be negatively associated with the stage of bladder cancer and overall survival of patients. However, the mechanisms regulating LASS2 in bladder cancer remain poorly understood. Here, we aim to identify a miRNA that targets LASS2 from bladder cancer-associated miRNAs and to reveal its potential functions in bladder cancer cells. Through miRNA microarray and bioinformatics analyses, we identified miR-3622a as a negative regulator of LASS2. The expression levels of miR-3622a in bladder cancer tissues were negatively correlated with the overall survival of patients. Overexpression of miR-3622a significantly increased the proliferation and invasion abilities of bladder cancer cells. In conclusion, our results indicate that miR-3622a promotes the proliferation and invasion of bladder cancer cells by downregulating LASS2. Copyright © 2019 Elsevier B.V. All rights reserved.

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出版当年[2019]版：

大类 | 3 区生物

小类 | 4 区遗传学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区遗传学

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第一作者机构： [1]Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Institute of Urology, Kunming 650101, China

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