机构：[1]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, Chin.[2]National Engineering Research Center of Biomedicine and Animal Science, Kunming, Yunnan, China.[3]Department of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming Medical College, Kunming, China.外科片肝胆外科云南省第一人民医院
Alcoholic liver disease (ALD) is a significant public health issue with heavy medical and economic burdens. The aetiology of ALD is not yet completely understood. The development of drugs and therapies for ALD is hampered by a lack of suitable animal models that replicate both the histological and metabolic features of human ALD. Here, we characterize a rhesus monkey model of alcohol-induced liver steatosis and hepatic fibrosis that is compatible with the clinical progression of the biochemistry and pathology in humans with ALD. Microarray analysis of hepatic gene expression was conducted to identify potential molecular signatures of ALD progression. The up-regulation of expression of hepatic genes related to liver steatosis (CPT1A, FASN, LEPR, RXRA, IGFBP1, PPARGC1A and SLC2A4) was detected in our rhesus model, as was the down-regulation of such genes (CYP7A1, HMGCR, GCK and PNPLA3) and the up-regulation of expression of hepatic genes related to liver cancer (E2F1, OPCML, FZD7, IGFBP1 and LEF1). Our results demonstrate that this ALD model reflects the clinical disease progression and hepatic gene expression observed in humans. These findings will be useful for increasing the understanding of ALD pathogenesis and will benefit the development of new therapeutic procedures and pharmacological reagents for treating ALD.
基金：
National Basic Research Program of China [2012CBA01305],
Scientific Innovation Project of the Chinese Academy of Science [XDA01040103], Kunming science
and technology planning project [2014-04-A-S-02-3074], Yunnan technology innovation talent project [2014HB090] and Yunnan young leaders in academic and technical talents project [2012HB040], Yunnan
technical innovation project [2015XA33].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
最新[2025]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
第一作者：
第一作者机构：[1]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, Chin.[2]National Engineering Research Center of Biomedicine and Animal Science, Kunming, Yunnan, China.
通讯作者：
通讯机构：[1]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, Chin.[2]National Engineering Research Center of Biomedicine and Animal Science, Kunming, Yunnan, China.
推荐引用方式(GB/T 7714)：
Wang Hong,Tan Tao,Wang Junfeng,et al.Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis.[J].Scientific reports.2015,5:15019.doi:10.1038/srep15019.
APA：
Wang Hong,Tan Tao,Wang Junfeng,Niu Yuyu,Yan Yaping...&Si Wei.(2015).Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis..Scientific reports,5,
MLA：
Wang Hong,et al."Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis.".Scientific reports 5.(2015):15019
