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Comparative study on the mutational profile of adenocarcinoma and squamous cell carcinoma predominant histologic subtypes in Chinese non-small cell lung cancer patients

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机构: [1]Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [2]Department of Pathology, Southeast University, Zhongda Hospital, Nanjing, China. [3]Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China. [4]Department of Pathology, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China. [5]Department of Pathology, Xiangya Hospital, Central South University, Changsha, China. [6]Molecular Diagnostic Center, Yunnan Cancer Center, Yunnan Cancer Hospital, Kunming, China. [7]Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China. [8]Burning Rock Biotech, Guangzhou, China.
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Distinction in the mutational profile between the common histological types, lung adenocarcinoma (LUAD) and squamous cell lung carcinoma (LUSC) has been well-established. However, comprehensive mutation profiles of the predominant histological subtypes within LUAD and LUSC remains elusive.We analyzed the mutational profile of 318 Chinese NSCLC patients of adenocarcinoma and squamous cell carcinoma predominant subtypes from seven hospitals using capture-based ultra-deep sequencing of 68 lung cancer-related genes.Of the 318 NSCLC patients, 215 were diagnosed with LUAD and 103 with LUSC. Adenocarcinoma in situ and acinar adenocarcinoma were the most predominant subtypes of LUAD. On the other hand, keratinizing squamous cell carcinoma was the most predominant subtype of LUSC. Among the LUAD subtypes, EGFR sensitizing mutations were most prevalent in the invasive lepidic subtype. More than half of the patients with preinvasive adenocarcinoma in situ, minimally invasive, acinar, micropapillary and papillary subtypes were also EGFR-mutants. Patients with colloidal, invasive mucinous, and fetal subtypes had the least number of EGFR mutations. Moreover, KRAS mutations were prevalent in patients with invasive mucinous, colloid, enteric and solid subtypes. A total of 90% of the LUSC patients harbor mutations in TP53, wherein all patients except five with nonkeratinizing were TP53 mutants. PIK3CA amplifications were most prevalent in keratinizing, followed by basaloid and nonkeratinizing subtypes.These data suggest that the mutational profiles among the predominant histological subtypes were very distinct, which provided a reliable tool to improve treatment decisions.© 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

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出版当年[2020]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学 3 区 呼吸系统
最新[2023]版:
大类 | 3 区 医学
小类 | 4 区 肿瘤学 4 区 呼吸系统
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出版当年[2019]版:
Q3 ONCOLOGY Q3 RESPIRATORY SYSTEM
最新[2023]版:
Q2 RESPIRATORY SYSTEM Q3 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [1]Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
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通讯机构: [1]Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [*1]Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, China
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