机构：[1]Shenzhen University Health Sciences Center, School of Basic Medical Sciences, Department of Physiology,Shenzhen, 518061, China深圳市康宁医院深圳医学信息中心[2]BGI-Yunnan, BGI-Shenzhen, Kunming, 650106, China[3]Dali University First affiliatedHospital, Dali, 671000, China. 4The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital ofYunnan Province), Kunming, 650000, China[5]Shenzhen Longgang ENT Institute, Shenzhen, 518100, China[6]Puer University, Puer School of BGI-Yunnan, Puer, 665000, China[7]Dali University, School of Basic MedicalSciences, Dali, 671003, China[8]BGI-Shenzhen, Shenzhen, 518083, China[9]James D. Watson Institute of GenomeSciences, Hangzhou, 310058, China. Shenmin
Regional gender differences in autosomal chromosome disorders have been observed repeatedly. However, the corresponding diversity changes remain unconfirmed. By analyzing previously published thalassemia data from the Dai people in Dehong and Xishuangbanna (two regions in Yunnan Province, China), we found that several sequence types, including HBA CNV and HBB mutations, significantly depend on gender in Xishuangbanna but not in Dehong. With the supportive evidence from previous researches, we accept that some certain mutations depend on gender regionally. This association seems peculiar. It is among one common people on a small geographical scale, while other recorded thalassemia gender difference varies by ethnics and continent.
基金：
This project was supported by grants from the National Science Foundation of China (Nos. 31500940 and
81260415), the Natural Science Foundation of Guangdong Province, China (No. 2016A030310037), the
Shenzhen Peacock Program scientific research start-up foundation, and the National Science Foundation of
Shenzhen University, China (No. C110205). This project was also supported by the foundation of the Natural
Science Foundation of Yunnan Province, China (Nos. 2013DA008, 2014FC003, 2015DA008, 2014HB053,
2016YFC0900503, 2016RA037 and 2016RA038).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
最新[2023]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
第一作者：
第一作者机构：[1]Shenzhen University Health Sciences Center, School of Basic Medical Sciences, Department of Physiology,Shenzhen, 518061, China[2]BGI-Yunnan, BGI-Shenzhen, Kunming, 650106, China
共同第一作者：
通讯作者：
通讯机构：[2]BGI-Yunnan, BGI-Shenzhen, Kunming, 650106, China[5]Shenzhen Longgang ENT Institute, Shenzhen, 518100, China[6]Puer University, Puer School of BGI-Yunnan, Puer, 665000, China[7]Dali University, School of Basic MedicalSciences, Dali, 671003, China
推荐引用方式(GB/T 7714)：
Shenmin Guan,Yingying Zhao,Xiao Zhuo,et al.Regional gender differences in an autosomal disease result in corresponding diversity differences.[J].Scientific reports.2019,9(1):5472.doi:10.1038/s41598-019-41905-8.
APA：
Shenmin Guan,Yingying Zhao,Xiao Zhuo,Wenhui Song,Xiaorui Geng...&Le Cheng.(2019).Regional gender differences in an autosomal disease result in corresponding diversity differences..Scientific reports,9,(1)
MLA：
Shenmin Guan,et al."Regional gender differences in an autosomal disease result in corresponding diversity differences.".Scientific reports 9..1(2019):5472
