Correlation between single nucleotide polymorphisms inCXCR4microRNA binding site and the susceptibility to knee osteoarthritis in Han Chinese population
Background This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) at the microRNA target sequence inCXCR4and the susceptibility to knee osteoarthritis (KOA). Methods A total of 305 patients with KOA and 305 healthy controls were recruited into this study. The genotypes ofCXCR4rs1804029 and rs17848060 loci were analyzed. Results The susceptibility to KOA ofCXCR4rs1804029 G allele carriers was 1.33 times (95% CI: 1.09-1.54,P = .006) that of T allele carriers. The KOA susceptibility in individuals carrying T allele atCXCR4rs17848060 locus was 1.38 times that of individuals carrying A allele (95% CI: 1.17-1.57,P < .001). The G allele atCXCR4rs1804029 locus was the target of hsa-miR-146a-3p, while the A allele atCXCR4rs17848060 locus could be targeted by hsa-miR-20a-3p. The plasma level of hsa-miR-146a-3p was lower in rs1804029 G allele carriers than T allele carriers (P < .001), whereas plasma level of hsa-miR-20a-3p was higher in rs17848060 T allele carriers than A allele carriers (P < .001). Conclusion The SNPs at rs1804029 and rs17848060 loci inCXCR4were significantly associated with the susceptibility to KOA in Han Chinese population.
基金：
This work was supported by the National
Natural Science Foundation of China (No:
30860286), Innovative Team Project in
Yunnan Province (No: 2014HC1018), and
Projects of International Cooperation in
Yunnan Province (No: 2013IA004).
第一作者机构：[1]Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
通讯作者：
通讯机构：[1]Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China[*1]Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China.
推荐引用方式(GB/T 7714)：
Yang Wang,Yanlin Li,Di Jia,et al.Correlation between single nucleotide polymorphisms inCXCR4microRNA binding site and the susceptibility to knee osteoarthritis in Han Chinese population[J].JOURNAL OF CLINICAL LABORATORY ANALYSIS.2021,35(2):doi:10.1002/jcla.23600.
APA：
Yang Wang,Yanlin Li,Di Jia,Jiali Zheng&Guoliang Wang.(2021).Correlation between single nucleotide polymorphisms inCXCR4microRNA binding site and the susceptibility to knee osteoarthritis in Han Chinese population.JOURNAL OF CLINICAL LABORATORY ANALYSIS,35,(2)
MLA：
Yang Wang,et al."Correlation between single nucleotide polymorphisms inCXCR4microRNA binding site and the susceptibility to knee osteoarthritis in Han Chinese population".JOURNAL OF CLINICAL LABORATORY ANALYSIS 35..2(2021)
