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Engineered nanoparticle-induced epigenetic changes: An important consideration in nanomedicine

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收录情况： ◇ SCIE

作者：
Weiyuan Zhang[a] * ; Sicheng Liu[b] * ; Dan Han[a] ; Zhiyong He[c] ;
机构： [a]Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan [b]Second Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan [c]Department of Anatomy and Developmental Biology, Monash University, 3800Clayton, Melbourne, Clayton
出处：
DOI： 10.1016/j.actbio.2020.09.034
ISSN：

关键词： Engineered nanomaterials Epigenetics High-throughput technology Inflammation MAPK pathway Oxidative stress

摘要：
Engineered nanoparticles (ENPs) are now being applied across a range of disciplines, and as a result numerous studies have now assessed ENP-related bioeffects. Among them, ENP-induced epigenetic changes including DNA methylation, histone modifications, and miRNA-mediated regulation of gene expression have recently attracted attention. In this review, we describe the diversity of ENP-induced epigenetic changes, focusing on their interplay with related functional biological events, especially oxidative stress, MAPK pathway activation, and inflammation. In doing so, we highlight the underlying mechanisms and biological effects of ENP-induced epigenetic changes. We also summarize how high-throughput technologies have helped to uncover ENP-induced epigenetic changes. Finally, we discuss future perspectives and the challenges related to ENP-induced epigenetic changes that still need to be addressed. © 2020

基金：
This work was supported by National Natural Science Foundation of China (81960310 and 81860254) and the Joint program of Yunnan Province and Kunming Medical University (2017FE468–249, Z.Y.H).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 工程技术
小类 | 2 区 工程：生物医学 2 区 材料科学：生物材料
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
JCR分区：
出版当年[2019]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Weiyuan Zhang,Sicheng Liu,Dan Han,et al.Engineered nanoparticle-induced epigenetic changes: An important consideration in nanomedicine[J].ACTA BIOMATERIALIA.2020,117:93-107.doi:10.1016/j.actbio.2020.09.034.
APA：
Weiyuan Zhang,Sicheng Liu,Dan Han&Zhiyong He.(2020).Engineered nanoparticle-induced epigenetic changes: An important consideration in nanomedicine.ACTA BIOMATERIALIA,117,
MLA：
Weiyuan Zhang,et al."Engineered nanoparticle-induced epigenetic changes: An important consideration in nanomedicine".ACTA BIOMATERIALIA 117.(2020):93-107

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