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Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow-ups and predictors of achieving treatment target

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收录情况： ◇ SCIE

作者：
Xiang, Yirong[1,2] * ; Wang, Qian[1,2] * ; Li, Hongbin[3] * ; Duan, Xinwang[4] ; Fang, Yongfei[5] ; Yang, Pingting[6] ; Li, Qin[7] ; Wu, Rui[8] ; Huo, Yuehong[9] ; Shi, Xiaofei[10] ; Wu, Zhenbiao[11] ; Wang, Yanhong[12] ; Jiang, Nan[1,2] ; Hsieh, Evelyn[13] ; Li, Mengtao[1,2] ; Tian, Xinping[1,2,*1] ; Zeng, Xiaofeng[1,2,*1] ; Chinese Registry of Rheumatoid Arthritis co-authors[1] ;
机构： [1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, National Clinical Research Center on Rheumatology, Ministry of Science & Technology, Beijing, China [2]Department of Rheumatology, The Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China [3]Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China [4]Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China [5]Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, China [6]Department of Rheumatology, The First People's Hospital of Yunnan Province, Kunming, China [7]Department of Rheumatology, The First Affiliated Hospital of Nanchang University, Nanchang, China 8 Department of Rheumatology, The Fifth People’s Hospital of Datong, Datong, China [8]Department of Rheumatology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China [9]Department of Clinical Immunology and Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Xi’an, China [10]Department of Epidemiology and Bio-statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China [11]Section of Rheumatology, Yale School of Medicine, New Haven, CT, USA
出处：
DOI： 10.1111/1756-185X.13996
ISSN：

关键词： disease activity predictors remission rheumatoid arthritis treat-to-target

摘要：
Aim The Chinese Registry of Rheumatoid Arthritis (CREDIT) is the first nationwide multi-center prospective rheumatoid arthritis (RA) registration cohort in China. This study aimed at presenting disease activities transition during follow-ups and identifying predictors to treatment response. Method Patients who had baseline, 3- and 6-month follow-up data from November 2016 to April 2018 were recruited. Then, we selected patients who did not reach remission (REM)/low disease activity (LDA) at baseline to investigate the predictors for treatment response. Results There were 979 patients included (83.00% female, mean age 51.8 and median duration 3.84 years). REM/LDA rate at baseline, 3-, and 6-month follow-up were 34.02%, 59.35% and 68.23%. Additionally, early RA has more chance to achieve targets than established RA (6 months: 59.79% vs 48.13%,P = .002). High baseline Disease Activity Score of 28 joints (DAS28) (early RA: odds ratio [OR] 1.319,P = .019; established RA: OR 1.337,P < .001), biologic disease-modifying anti-rheumatic drugs (bDMARD)/targeted synthetic DMARD combined conventional DMARD therapy (early RA: OR 9.023,P = .046) and prednisolone usage (early RA: OR 2.526,P < .001) are positively associated with Clinical Disease Assessment Index (CDAI) decreasing at 3 months. Low baseline DAS28 (REM/LDA: early RA: OR 0.650,P < .001; established RA: OR 0.612,P < .001. REM: early RA: OR 0.743,P = .021; established RA: OR 0.674,P < .001), young age (REM: early RA: OR 0.977,P = .048) and decrease of CDAI at 3 months (REM/LDA: early RA: OR 7.185,P < .001; established RA: OR 8.752,P < .001. REM: early RA: OR 5.602,P < .001; established RA: OR 4.955,P < .001) predict REM/LDA at 6 months. Conclusion Disease activity decreased during follow-ups. Disease duration, baseline disease activity, age, treatment strategies, and CDAI decreasing were associated with treatment response.

基金：
Chinese National Key Research RD Program [2017YFC0907601, 2017YFC0907604]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 4 区 医学
小类 | 4 区 风湿病学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 风湿病学
JCR分区：
出版当年[2019]版：
Q4 RHEUMATOLOGY
最新[2023]版：
Q2 RHEUMATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, National Clinical Research Center on Rheumatology, Ministry of Science & Technology, Beijing, China [2]Department of Rheumatology, The Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, National Clinical Research Center on Rheumatology, Ministry of Science & Technology, Beijing, China [2]Department of Rheumatology, The Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China [*1]Department of Rheumatology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing Ave, 100730, Beijing, China.
推荐引用方式(GB/T 7714)：
Xiang Yirong,Wang Qian,Li Hongbin,et al.Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow-ups and predictors of achieving treatment target[J].INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES.2020,23(12):1719-1727.doi:10.1111/1756-185X.13996.
APA：
Xiang, Yirong,Wang, Qian,Li, Hongbin,Duan, Xinwang,Fang, Yongfei...&Chinese Registry of Rheumatoid Arthritis co-authors.(2020).Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow-ups and predictors of achieving treatment target.INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,23,(12)
MLA：
Xiang, Yirong,et al."Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow-ups and predictors of achieving treatment target".INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 23..12(2020):1719-1727

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