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Heat shock transcription factor 2 reduces the secretion of IL-1β by inhibiting NLRP3 inflammasome activation in ulcerative colitis

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收录情况： ◇ SCIE

作者：
Fengrui Zhang[a] * ; Wei Zhao[b] * ; Jiao Zhou[b] ; Wen Wang[b] ; Juan Luo[a] ; Yuran Feng[c] ; Jing Wu[a] ; Maojuan Li[a] ; Kunhua Wang[d] ; Junkun Niu[a] ; Yinglei Miao[a] ;
机构： [a]Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Diseases, Kunming 650032, China [b]Kunming Medical University, Kunming 650032, China [c]Department of Ultrasound, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [d]Department of General Surgery, First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Diseases, Kunming 650032, China
出处：
DOI： 10.1016/j.gene.2020.145299
ISSN：

关键词： Heat-shock transcription factor 2 Inflammation NLRP3 inflammasome Pathogenesis Ulcerative colitis

摘要：
Ulcerative colitis (UC) is a chronic inflammatory disease with unknown aetiology. As a pro-inflammatory cytokine, interleukin-1β (IL-1β) plays a critical, damaging role in UC. Heat shock proteins (HSPs) are important anti-inflammatory factors that maintain intestinal epithelial cells (IECs) homeostasis. Heat shock transcription factor 2 (HSF2) is an important regulator of HSPs. In our previous research, we found that HSF2 is highly expressed in UC, is negatively related to colon inflammation of mice, and inhibits the expression of IL-1β, but the specific mechanism is still unclear. As a product of the NLRP3 inflammasome, the expression of IL-1β is closely related to NLRP3 inflammasome activation. Therefore, we hypothesised that HSF2 affects the secretion of IL-1β by regulating activation of the NLRP3 inflammasome. In this study, hsf−/− DSS model mice showed highest levels of expression of the NLRP3 inflammasome and the secretion of IL-1β. In Caco-2 cells, the levels of expression of the NLRP3 inflammasome and the secretion of IL-1β were inhibited by overexpression of HSF2, and inhibited HSF2 increased activation of the NLRP3 inflammasome and the secretion of IL-1β. These findings indicated that HSF2 might be an important target for inflammatory modulation in UC. © 2020 Elsevier B.V.

基金：
This work was supported by National Natural Science Foundation of China ( U1802282 , 81960108 , 81660100 , 81670501 ); MDT Innovation Team to Digestive Diseases of S&T Department of Yunnan Province (2017HC005).
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外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 生物
小类 | 3 区 遗传学
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 遗传学
JCR分区：
出版当年[2020]版：
Q2 GENETICS & HEREDITY
最新[2023]版：
Q2 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [a]Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Diseases, Kunming 650032, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Fengrui Zhang,Wei Zhao,Jiao Zhou,et al.Heat shock transcription factor 2 reduces the secretion of IL-1β by inhibiting NLRP3 inflammasome activation in ulcerative colitis[J].GENE.2021,768:doi:10.1016/j.gene.2020.145299.
APA：
Fengrui Zhang,Wei Zhao,Jiao Zhou,Wen Wang,Juan Luo...&Yinglei Miao.(2021).Heat shock transcription factor 2 reduces the secretion of IL-1β by inhibiting NLRP3 inflammasome activation in ulcerative colitis.GENE,768,
MLA：
Fengrui Zhang,et al."Heat shock transcription factor 2 reduces the secretion of IL-1β by inhibiting NLRP3 inflammasome activation in ulcerative colitis".GENE 768.(2021)

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