机构：[1]Allergy Research Center, Zhejiang University, Hangzhou, 310058, China.[2]College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.[3]Department of Allergy, Yu Huang Ding Hospital, Yantai, 264001, Shandong, China.[4]Hangzhou Aileji Biotech Ltd, Hangzhou, China.[5]Department of Allergy, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310013, China.[6]Department of Allergy, The Third People’s Hospital of Datong, Shanxi, 037008, China[7]Department of Otorhinolaryngology, Qujing Chinese Traditional Medicine Hospital, Yunnan, China.[8]Department of Otorhinolaryngology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, Shanxi, 030012, China[9]Department of Respiratory Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310013，China浙江大学医学院附属第一医院[10]Department of Biosciences, University of Salzburg, Hellbrunnerstrasse 34, A-5020, Salzburg, Austria[11]Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
Background Artemisia pollen allergy is a major cause of asthma in Northern China. Possible associations between IgE responses to Artemisia allergen components and clinical phenotypes have not yet been evaluated. This study was to establish sensitization patterns of four Artemisia allergens and possible associations with demographic characteristics and clinical phenotypes in three areas of China. Methods Two hundred and forty patients allergic to Artemisia pollen were examined, 178 from Shanxi and 30 from Shandong Provinces in Northern China, and 32 from Yunnan Province in Southwestern China. Allergic asthma, rhinitis, conjunctivitis, and eczema symptoms were diagnosed. All patients' sera were tested by ImmunoCAP with mugwort pollen extract and the natural components nArt v 1, nArt ar 2, nArt v 3, and nArt an 7. Results The frequency of sensitization and the IgE levels of the four components in Artemisia allergic patients from Southwestern China were significantly lower than in those from the North. Art v 1 and Art an 7 were the most frequently recognized allergens (84% and 87%, respectively), followed by Art v 3 (66%) and Art ar 2 (48%). Patients from Northern China were more likely to have allergic asthma (50%) than patients from Southwestern China (3%), and being sensitized to more than two allergens increased the risk of allergic asthma, in which co-sensitization to three major allergens Art v 1, Art v 3, and Art an 7 is prominent. Conclusions Component-resolved diagnosis of Chinese Artemisia pollen-allergic patients helps assess the potential risk of mugwort-associated allergic asthma.
基金：
Hangzhou Aileji Biotech Ltd, China (2016-R1) and by the Natural Science Foundation of China (31772271).
第一作者机构：[1]Allergy Research Center, Zhejiang University, Hangzhou, 310058, China.[2]College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.[*1]Allergy Research Center and College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China
共同第一作者：
通讯作者：
通讯机构：[1]Allergy Research Center, Zhejiang University, Hangzhou, 310058, China.[2]College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.[*1]Allergy Research Center and College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China
推荐引用方式(GB/T 7714)：
Gao Zhongshan,Fu Wan-Yi,Sun Yuemei,et al.Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization[J].ALLERGY.2019,74(2):284-293.doi:10.1111/all.13597.
医学