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Lymphocyte-based ratios for predicting respiratory failure in Guillain-Barré syndrome

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机构: [a]Department of Neurology, West China Hospital, Sichuan University, 37, Guo Xue Xiang, Chengdu, Sichuan Province [b]Department of Neurology, Seventh People's Hospital of Chengdu, No. 1, Twelve Middle Street, Wuhou District, Chengdu, Sichuan Province [c]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 295, Xi Change Road, Kunming, Yunnan Province
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关键词: Guillain-Barré syndrome Neutrophil to lymphocyte Platelet to lymphocyte Respiratory failure

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Purpose: Up to 20–30% of patients with Guillain-Barré syndrome (GBS) suffer serious clinical manifestations such as respiratory failure. We aim to determine whether two new prognostic biomarkers, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), could reliably predict respiratory failure in GBS.we Materials and methods: Data from 426 patients diagnosed at our center with GBS between January 2015 and July 2019 were retrospectively analyzed. Data were collected from the hospital database. Logistic regression and receiver operating characteristic curves were used to examine whether NLR alone, PLR alone or the combination, as measured at admission, could predict respiratory failure during hospitalization. Nomograms for predicting respiratory failure in GBS individuals were established, and predictive accuracy was evaluated using Harrell's concordance index (C-index). Results: A total of 74 (17%) patients developed respiratory failure during hospitalization, and this was predicted independently by neutrophil count, NLR, PLR, and a combined “NLR-PLR” index, with the combined index performing best. The C-index of nomograms was 0.952 (95%CI 0.930–0.974) when NLR-PLR was included, or 0.933 (95%CI 0.911–0.955) when it was excluded. Conclusions: The prognostic biomarkers NLR and PLR may be independent predictors of respiratory failure in GBS. Combining the two indices may be more effective than either one on its own. © 2021 Elsevier B.V.

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出版当年[2021]版:
大类 | 3 区 医学
小类 | 3 区 神经科学 4 区 免疫学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 神经科学
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出版当年[2020]版:
Q3 IMMUNOLOGY Q3 NEUROSCIENCES
最新[2023]版:
Q2 NEUROSCIENCES Q3 IMMUNOLOGY

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第一作者机构: [a]Department of Neurology, West China Hospital, Sichuan University, 37, Guo Xue Xiang, Chengdu, Sichuan Province
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