详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

2D Ti3C2TxMXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou 2150 0 0, China [2]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [3]Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, Nanjing 210096, China [4]Institute for Regenerative Medicine, Shanghai East Hospital, School of Materials Science and Engineering, Tongji University, Shanghai 20 0 092, China [5]Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China

出处：

DOI：

ISSN：

摘要：

Preclinical studies involving stem cells require efficient physiochemical regulations on the fate of such cells. Because of their unique planar structure, metallic conductivity, and flexible surface functionalization, MXenes show potential for modulating stem cell fate. Here, the Ti3C2TxMXenenanosheets are dispersed on tissue culture polystyrene (TCPS). When primary mouse neural stem cells (NSCs) are cultured on laminin-coated Ti3C2TxMXene film, they form stable adhesion, retain their proliferative ability, and show extensive spreading of terminal extensions. With respect to their functional activity, NSCs cultured on Ti3C2TxMXene films form more active and synchronous network activity than those cultured on TCPS substrates. Moreover, Ti3C2TxMXene film significantly promotes the neural differentiation and the neurons have longer neurites and greater numbers of branch points and branch tips. NSC-derived neurons grown on the Ti3C2Tx MXene film preserved normal synapse development. Finally, electrical stimulation coupled with Ti3C2TxMXene film significantly enhances the proliferation of NSCs. These results indicate that Ti3C2TxMXene is an efficient interface for the proliferation and neural differentiation of NSC and the maturation of NSC-derived neurons, which expands the potential uses of the MXene family of materials and provides new strategies for stem cell studies. Copyright © 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 1 区

工程技术

小类 | 2 区工程：生物医学 2 区材料科学：生物材料

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

第一作者：

第一作者机构： [1]Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou 2150 0 0, China [2]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [3]Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, Nanjing 210096, China

共同第一作者：

通讯作者：

通讯机构： [1]Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou 2150 0 0, China [3]Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, Nanjing 210096, China [5]Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China

推荐引用方式(GB/T 7714)：

APA：

MLA：